Epidemiology of Carotid Artery Atherosclerosis in Youth

青少年颈动脉粥样硬化的流行病学

• 批准号: 6823032
• 负责人: PATRICIA Helen DAVIS
• 金额: $ 62.47万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-09-30 至 2008-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6823032
• 关键词: acute phase protein; adolescence (12-20); age difference; aorta disorder; atherosclerosis; blood chemistry; blood pressure; body composition; cardiovascular disorder diagnosis; cardiovascular disorder epidemiology; cardiovascular disorder risk; carotid artery; clinical research; early diagnosis; family genetics; gender difference; hemoglobin As; human birth weight; human middle age (35-64); human subject; lipid metabolism; longitudinal human study; questionnaires; smoking; young adult human (21-34)

DESCRIPTION (provided by applicant): The atherosclerotic process begins in childhood with the appearance of fatty streaks in the distal abdominal aorta and later affects the carotid and coronary arteries. Identification of children and adolescents at high risk for atherosclerosis would allow early intervention before the development of symptoms. Measurement of carotid intimal-medial thickness (IMT) detects subclinical disease and is predictive of coronary artery disease, stroke and peripheral vascular disease in older adults. In 1970, cardiovascular risk factors (CRF) were measured in school age children in Muscatine, Iowa. A representative sample of 675 members of this initial cohort are now aged 42 to 50 years. Risk factors were measured in childhood, young adulthood, and three times as older adults. In addition, measures of subclinical disease including carotid IMT, coronary artery calcification (CAC) and brachial artery flow-mediated dilatation have been completed. Carotid IMT in young and middle-aged adults is related to childhood risk factors including cholesterol in both genders and obesity in women. Carotid IMT is significantly associated with CAC and current CRF. In 442 of the offspring of this cohort, aged 15 to 30 years, carotid IMT is not related to CRF but CRF in the offspring are related to parental carotid IMT. Carotid IMT is correlated within siblings and with parental IMT suggesting that there is familial aggregation of carotid IMT. In this application, we will measure IMT in a vascular bed affected earlier by atherosclerosis, the distal abdominal aorta, as well as in the carotid artery. In 662 offspring, aged 11 to 32 years, we will determine (1) if aortic and carotid IMT are related (2) the relationship of CRF to aortic IMT and progression of carotid IMT and (3) the relationship of aortic and carotid IMT in the offspring to subclinical (as measured by progression of carotid IMT) or clinical (cardiovascular morbidity or mortality) disease in their parents. This proposal has the potential of providing information which would allow identification of individuals at high risk of atherosclerosis during childhood or adolescence.

描述（由申请人提供）：动脉粥样硬化过程始于童年时期，腹主动脉远端的脂肪条纹出现，后来影响颈动脉和冠状动脉。鉴定有动脉粥样硬化的儿童和青少年可能会在症状发展之前尽早干预。颈动脉内膜厚度（IMT）的测量可检测亚临床疾病，并预测老年人的冠状动脉疾病，中风和外周血管疾病。 1970年，在爱荷华州穆斯卡汀（Muscatine）的学龄儿童中测量了心血管危险因素（CRF）。该初始队列的675名成员的代表性样本现在年龄在42至50岁之间。危险因素是在儿童期，成年时期测量的，是老年人的三倍。此外，已经完成了包括颈动脉IMT，冠状动脉钙化（CAC）和臂动脉流介导的扩张在内的亚临床疾病的测量。年轻和中年成年人的颈动脉IMT与儿童时期危险因素有关，包括性别的胆固醇和女性的肥胖。颈动脉IMT与CAC和电流CRF显着相关。在该同龄人的后代的442年中，年龄在15至30岁之间，Carotid IMT与CRF无关，但后代的CRF与父母的颈动脉IMT有关。颈动脉IMT在兄弟姐妹中相关，并与父母IMT相关，表明颈动脉IMT有家族性聚集。在此应用中，我们将测量受动脉粥样硬化，腹主动脉远端以及颈动脉影响的血管床中的IMT。 In 662 offspring, aged 11 to 32 years, we will determine (1) if aortic and carotid IMT are related (2) the relationship of CRF to aortic IMT and progression of carotid IMT and (3) the relationship of aortic and carotid IMT in the offspring to subclinical (as measured by progression of carotid IMT) or clinical (cardiovascular morbidity or mortality) disease in their 父母。该提案具有提供信息的潜力，该信息将允许在儿童期或青少年期间识别具有高风险的人。