Exercise Intervention on Cortisol Secretion and Cardiovascular Disease Risk

运动干预对皮质醇分泌和心血管疾病风险的影响

• 批准号: 7157762
• 负责人: NOHA Hassan FARAG
• 金额: $ 6.58万
• 依托单位: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-04 至 2009-09-03
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7157762
• 关键词: Native Americans; adolescence (12-20); age difference; blood pressure; body weight; cardiovascular disorder prevention; cardiovascular disorder risk; caucasian American; clinical research; cortisol; exercise; hormone regulation /control mechanism; human subject; human therapy evaluation; hypothalamic pituitary adrenal axis; metabolic syndrome; obesity; patient oriented research; postdoctoral investigator; racial /ethnic difference; saliva; secretion; weight control

DESCRIPTION (provided by applicant): The prevalence of obesity in children and adolescents is increasing at an alarming rate. Evidence exists that childhood obesity is associated with an increased risk of morbidity and mortality through adulthood. The US population has moved towards a sedentary life style, which has further exacerbated the obesity epidemic. Central body fat deposition has emerged as an important predictor of the health hazards of obesity. Increased levels of cortisol cause central fat deposition characteristic of the metabolic syndrome. The function of the hypothalamic-pituitary-adrenal axis in obesity has been studied in adults. The correlation between cortisol and the cardiovascular disease risk profile in adolescents is not well established, particularly as related to obesity. Native Americans have a higher incidence of obesity and cardiovascular disease. In this study, we will determine correlates of salivary cortisol in adolescents living in Anadarko, a central location of the Seven Tribes of Southwest Oklahoma. We will also examine the effect of a 12-week standardized exercise training program on salivary cortisol and the cardiovascular disease risk profile in at risk adolescents.

描述（由申请人提供）：儿童和青少年肥胖的患病率正在以惊人的速度增加。有证据表明，儿童肥胖与成年后发病和死亡风险增加有关。美国人口已经转向久坐的生活方式，这进一步加剧了肥胖的流行。中央身体脂肪沉积已成为肥胖对健康危害的重要预测指标。皮质醇水平升高会导致代谢综合征特征的中央脂肪沉积。下丘脑-垂体-肾上腺轴在肥胖中的功能已在成人中进行了研究。皮质醇与青少年心血管疾病风险之间的相关性尚未明确，特别是与肥胖相关。美洲原住民肥胖和心血管疾病的发病率较高。在这项研究中，我们将确定居住在阿纳达科（俄克拉荷马州西南部七个部落的中心位置）的青少年唾液皮质醇的相关性。我们还将研究为期 12 周的标准化运动训练计划对高危青少年唾液皮质醇和心血管疾病风险状况的影响。