EPIDEMIOLOGY OF CAROTID ARTERY ATHEROSCLEROSIS IN YOUTH

青年颈动脉粥样硬化的流行病学

• 批准号: 6537210
• 负责人: PATRICIA Helen DAVIS
• 金额: $ 55.02万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-09-30 至 2004-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6537210
• 关键词: acute phase protein; adolescence (12-20); adult human (21+); angiocardioultrasonography; atherosclerosis; blood chemistry; cardiovascular disorder diagnosis; cardiovascular disorder epidemiology; carotid artery; clinical research; computed axial tomography; disease /disorder onset; disease /disorder proneness /risk; early diagnosis; family genetics; human subject; longitudinal human study; young adult human (21-34)

DESCRIPTION: (Adapted from Investigator's Abstract) The atherosclerotic process begins in childhood and progresses through adult life resulting in coronary heart disease (CHD), stroke, and peripheral vascular disease. There is a need to identify young people at risk for premature atherosclerosis so that preventive measures can be instituted before occlusive vascular disease occurs. The ultrasonic measurement of carotid intimal-medial thickness (IMT) allows detection of early atherosclerosis and is related to incident CHD and stroke in older adults. In 1970, a population of school age children and adolescents was first examined in Muscatine, Iowa. A sample of 776 members of this longitudinal cohort, who are representative of the initial childhood population, is now aged 37 to 45 years. Their risk factors were measured in childhood, young adulthood and twice in later adult life, and they have undergone measurement of carotid IMT as well as electron beam computed tomography to identify coronary artery calcification (CAC). In this cohort, carotid IMT is significantly associated with CAC as well as current LDL cholesterol and systolic blood pressure, but only 14 percent of carotid IMT variability can be explained by these risk factors. Parents of the cohort have been assessed for cardiovascular morbidity and mortality. In this application the investigators propose to do the following: (1) examine the third generation to determine whether the offspring of cohort members with premature atherosclerosis and/or a familial history of cardiovascular disease have increased carotid IMT or elevated risk factors; (2) identify risk factors for progression of carotid IMT over four years in this cohort; and (3) measure putative risk factors for increased IMT (serologic evidence of Clamydia pneumoniae or cytomegalovirus infection, high sensitivity C-reactive protein, fibrinogen, plasminogen activator inhibitor-1 and glycosylated hemoglobin). The investigators state that the study has the potential of providing information which would allow identification of subjects at risk for atherosclerosis at an early age and may lead the way to interventions to halt or slow progression of atherosclerosis prior to the development of clinical disease.

描述：（根据研究者的摘要进行了改编）动脉粥样硬化过程 从童年开始，并从成年生活发展，导致冠状动脉 心脏病（CHD），中风和周围血管疾病。有需要 确定有可能发生早产动脉粥样硬化风险的年轻人 在闭塞性血管疾病发生之前，可以采取预防措施。 颈动脉内膜厚度（IMT）的超声测量允许 检测早期动脉粥样硬化，与事件冠心病和中风有关 老年人。 1970年，一群学龄儿童和青少年是 首先在爱荷华州穆斯卡汀进行检查。该纵向的776名成员的样本 同时代表最初儿童期的人群现在已经老化了 37至45年。他们的危险因素是在童年时期衡量的 在后来的成年生活中两次，他们进行了颈动脉的测量 IMT以及电子束计算机断层扫描以识别冠状动脉 钙化（CAC）。在此队列中，颈动脉IMT显着相关 使用CAC以及当前的LDL胆固醇和收缩压，但 这些风险只能解释颈动脉IMT变异性的14％ 因素。该队列的父母已经评估了心血管发病率 和死亡率。在此应用程序中，调查人员建议做 以下：（1）检查第三代以确定后代是否 同伴过早动脉粥样硬化和/或家族历史的队列成员 心血管疾病增加了颈动脉IMT或危险因素升高； （2） 确定四年来颈动脉IMT进展的风险因素 队列； （3）衡量增加IMT的假定风险因素（血清学 肺炎肿瘤或巨细胞病毒感染的证据，高灵敏度 C反应蛋白，纤维蛋白原，纤溶酶原激活剂抑制剂1和 糖基化血红蛋白）。调查人员指出，该研究具有 提供可以识别主题的信息的潜力 在早期有动脉粥样硬化的风险，可能会导致 在停止或缓慢进展的动脉粥样硬化的干预措施之前 临床疾病的发展。