CORE--ANIMAL

核心--动物

• 批准号: 6578749
• 负责人: STANLEY B PRUSINER
• 金额: $ 28.58万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-04-01 至 2003-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6578749
• 关键词: animal breeding; animal care; animal colony; bioassay; biomedical facility; genetically modified animals; hamsters; immunologic assay /test; laboratory mouse; laboratory rabbit; neural degeneration; prions; protein purification; scrapie; tissue /cell preparation

The function of the Animal Core is to produce and maintain all of the animals required for the scientific projects for this and several other program project grants. The specific services of the Animal Core personnel includes: 1) Production of transgenic and knockout mice, 2) Production of transgenic and knockout mice, 2) Production of large volumes and scrapie-infected hamster brains for purification, 3) Performing experimental inoculations, neurological scoring of animals, data collection,, and tissue collection, 4) Providing transportation of animals and tissues between the laboratory and the animal facility, 5) Production of antibodies in mice and rabbits for experimental use, 6) Providing all animal care and veterinary care. The Animal Core operates in two purpose-built facilities in the Hunter's Point area of San Francisco, approximately 12 miles from the main UCSF campus. Its activities are directed by Dr. Prusiner and Dr. Marilyn Torchia, a laboratory animal veterinarian. Building 830B is a new nine room transgenic mouse breeding facility which houses our large breeding colony. Building 830 houses all the experimental animals in 21 rooms, under 21 rooms, under BSL 2 and 3 biocontainment.

动物核心的功能是生产和维持本项目和其他几个项目拨款的科学项目所需的所有动物。动物核心人员的具体服务包括：1）转基因和基因敲除小鼠的生产，2）转基因和基因敲除小鼠的生产，2）大量生产感染痒病的仓鼠大脑进行纯化，3）进行实验接种，神经学动物评分、数据收集和组织收集，4) 在实验室和动物设施之间提供动物和组织的运输，5) 在小鼠和兔子中生产供实验使用的抗体，6) 提供所有动物护理和兽医护理。 Animal Core 在旧金山 Hunter's Point 地区的两个专用设施中运营，距离加州大学旧金山分校主校区约 12 英里。其活动由 Prusiner 博士和实验动物兽医 Marilyn Torchia 博士指导。 830B 楼是一个新的九个房间的转基因小鼠饲养设施，里面有我们的大型繁殖群。 830 号楼的 21 个房间、21 个房间下的所有实验动物均位于 BSL 2 和 3 级生物防护之下。