动物源性饲料中典型PPCPs的风险评估

Pharmaceuticals and personal care products (PPCPs) have become one of the most important risk factors for Environmental safe. PPCPs have been survived in Animal Derived Feed.through PPCPs directly administered to poultry and other food animals. Then they have threatened human health through food chain. But Risk Assessment about PPCPs in Animal Derived Feed remains unknown. because of very few study about PPCPs in Animal Derived Feeds. This research aims to develop a confirmatory method for simultaneously determining six type of PPCPs (antimicrobial drugs, sulfanilamide, mental drug, sedatives, analgesic-antipyretic and steroids) in three Animal Derived Feed(meat meal ,fish meal,feather meal,), and investigated the PPCPs pollution status and their distribution characters in commercially Animal Derived Feed .the Filtering System of the Priority control for PPCPs in animal derived feed have been established based on data analyze. Risk on there PPCPs with high harm have be Assessed. This study will give valuable information for evaluating PPCPs effect to human health, as well as benefit to formulate scientific risk assessment tactics on Livestock environment.

近年来,PPCPs 成为热点关注的环境风险因子之一。由于动物养殖中大量使用PPCPs，造成PPCPs大量残留于动物源性饲料中，进而通过食物链，危害人类健康。目前对动物性饲料中PPCPs的相关研究不足, 尚不能反映动物性饲料中PPCPs的风险状况。本项目拟建立3种主要动物源性饲料（肉粉、鱼粉、羽毛粉）中6 类典型PPCPs（抗生素药物，磺胺类药物、精神类药物、镇静剂类药物、解热镇痛药，激素类）的检测技术。在此基础上，分析PPCPs在动物源性饲料的残留情况、污染水平、分布特征。通过数据分析，建立动物性饲料原料中PPCPs优先控制筛选体系。利用筛选系统，从动物性源饲料中筛选出高危害性的PPCPs，进行风险评估。项目的实施对于科学评价PPCPs对畜禽环境和人类健康的影响具有重要意义。

近年来,PPCPs 成为热点关注的环境风险因子之一。由于动物养殖中大量使用PPCPs，造成PPCPs大量残留于动物源性饲料中，进而通过食物链，危害人类健康。目前对动物性饲料中PPCPs的相关研究不足, 尚不能反映动物性饲料中PPCPs的风险状况。本项目建立了主要动物源性饲料（血粉、鱼粉、羽毛粉、肉粉）中6 类142种PPCPS（抗生素、精神类药物、镇静剂类药物、解热镇痛药，类固醇类、激动剂类药物等）的高通量快速检测技术和部分典型PPCPS的精准定量技术。应用所建立技术，分析了 PPCPs在血粉、鱼粉、羽毛粉、肉粉的残留情况、污染水平、分布特征。通过风险评价，构建了动物源性饲料中PPCPs风险评估模型和筛选系统。通过数据分析，从动物源性饲料中筛选出2类高风险的PPCPs药物，同时对进行来源初步分析研究，提醒管理者对这些物质进行重点关注。

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