Effectiveness of PTSD Treatment: PE vs Zoloft

PTSD 治疗的有效性：PE 与左洛复

• 批准号: 6840418
• 负责人: NORAH C FEENY
• 金额: $ 30.58万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-01-01 至 2008-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6840418
• 关键词: behavioral /social science research tag; clinical research; cognitive behavior therapy; cost effectiveness; decision making; functional ability; human subject; human therapy evaluation; interview; longitudinal human study; mental disorder chemotherapy; patient oriented research; posttraumatic stress disorder; psychopathology; sertraline; therapy compliance

DESCRIPTION (provided by application): Posttraumatic stress disorder (PTSD) is a chronic and debilitating condition, with lifetime prevalence rates ranging from 8%-14% of the US population (Davidson et at., 1991; Breslau et al., 1991, 1998; Kessler et al., 1995). Thus, the development of efficacious and cost-effective treatments for PTSD is imperative. Both prolonged exposure therapy (PE) and sertraline (MED) are of established efficacy for PTSD. Yet, we know very little about the comparable effectiveness of these forms of treatment, nor what factors influence treatment acceptance/refusal and completion/drop-out. In this five-year, two-site study, we will examine these issues. This collaborative R01 grant will be conducted at the University of Washington under the direction of Dr. Zoellner and at Case Western Reserve University under the direction of Dr. Feeny. We will conduct a hybrid efficacy-effectiveness trial in which female and male trauma victims will be randomly assigned to either choice or no choice treatment conditions. In the choice condition, participants will choose between prolonged exposure and sertraline. In the no choice condition, participants will be randomly assigned to either prolonged exposure or sertraline. Outcome, as measured by both psychopathology and broader functioning measures, will be assessed through 24-month follow-up. The results of the proposed research will inform clinicians about the relative short-term and long-term effectiveness of PE and MED, provide information about how these treatments influence broader measures of functional impairment, provide information regarding decision making factors in order to maximize treatment utilization, and provide important information about cost effectiveness of both PE and MED for chronic PTSD.

描述（由应用提供）：创伤后应激障碍（PTSD）是一种慢性且令人衰弱的状况，终生患病率从美国人群的8％-14％（Davidson et。，1991; Breslau等，1991，1991，1991，1998; Kessler等人； Kessler等人，1995年）。因此，必须开发有效且具有成本效益的PTSD治疗方法。长期暴露疗法（PE）和舍曲林（MED）均具有PTSD的疗效。然而，我们对这些形式的治疗形式的可比效率知之甚少，也不影响哪些因素影响治疗接受/拒绝和完成/退出。在这项五年的两次研究中，我们将研究这些问题。这项合作R01赠款将在Zoellner博士和Case Western Reserve University的指导下在Feeny博士的指导下在华盛顿大学进行。我们将进行一项混合功效效应试验，其中女性和男性创伤受害者将被随机分配到选择或没有选择治疗条件。在选择条件下，参与者将在长时间的暴露和舍曲林之间进行选择。在无选择的条件下，参与者将被随机分配为长时间的暴露或舍曲林。通过精神病理学和更广泛的功能措施来衡量的结果将通过24个月的随访进行评估。拟议研究的结果将为临床医生提供有关PE和MED的相对短期和长期有效性，提供有关这些治疗方法如何影响更广泛的功能障碍衡量的信息，提供有关决策因素的信息，以最大程度地提高治疗方法，并提供有关PE和MED的重要信息。