TREATMENT FOR PTSD: PROLONGED EXPOSURE THERAPY VS ZOLOFT

创伤后应激障碍 (PTSD) 的治疗：长期暴露疗法 VS 佐洛复

• 批准号: 7378056
• 负责人: NORAH C FEENY
• 金额: $ 3.02万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7378056
• 关键词: TREATMENT; PTSD; PROLONGED; EXPOSURE; THERAPY

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Posttraumatic stress disorder (PTSD) is a chronic and debilitating condition for which the development of efficacious and cost-effective treatments for PTSD is imperative. Both prolonged exposure therapy (PE) and Zoloft (MED) are of established efficacy for PTSD, yet little is known about the comparable effectiveness of these forms of treatment, nor what factors influence treatment acceptance/refusal and completion/drop-out. This five-year, two-site study will examine these issues. This is a collaborative R01 grant and will be conducted at the University of Washington and at Case Western Reserve University. This study is a hybrid efficacy-effectiveness trial in which female and male trauma victims will be randomly assigned to either choice or no choice treatment conditions. In the choice condition, participants will choose between PE, MED, or no treatment. In the no choice condition, participants will be randomly assigned to either PE or MED. Outcome, as measured by both psychopathology and broader functioning measures, will be assessed through 24-month follow-up. The results of the proposed research will inform clinicians about the relative short-term and long-term effectiveness of PE and MED, provide information about how these treatments influence broader measures of functional impairment, provide information regarding decision making factors in order to maximize treatment utilization, and provide important information about cost effectiveness of both PE and MED for chronic PTSD. GCRC is only needed for blood and urine tests at the screening visit for those subjects starting MED therapy. 180 subjects will be enrolled at each of the two study sites.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。创伤后应激障碍（PTSD）是一种慢性且令人衰弱的疾病，为PTSD的有效且具有成本效益的疗法的发展是必须的。长时间的暴露疗法（PE）和Zoloft（MED）均具有对PTSD的确定功效，但对这些形式的治疗形式的可比效率知之甚少，也不影响哪些因素影响治疗的接受/拒绝和完成/退出。这项五年的两次研究将研究这些问题。这是一项合作的R01赠款，将在华盛顿大学和凯斯西部储备大学进行。这项研究是一项混合效能试验，其中男性和男性创伤受害者将被随机分配到选择或没有选择治疗条件。在选择条件下，参与者将在PE，MED或不治疗之间进行选择。在无选择的条件下，参与者将被随机分配给PE或MED。通过精神病理学和更广泛的功能措施来衡量的结果将通过24个月的随访进行评估。拟议研究的结果将为临床医生提供有关PE和MED的相对短期和长期有效性，提供有关这些治疗方法如何影响更广泛的功能障碍衡量的信息，提供有关决策因素的信息，以最大程度地提高治疗方法，并提供有关PE和MED的重要信息。 GCRC仅在筛查访问时需要进行血液和尿液检查，以开始进行MED疗法。在两个研究地点的每个站点中，每个受试者将有180名受试者。