Adolescents at High Risk for Familial Bipolar Disorder.

青少年患有家族性双相情感障碍的高风险。

• 批准号: 6875444
• 负责人: MELVIN G MCINNIS
• 金额: $ 29.33万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-05-19 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6875444
• 关键词: adolescence (12-20); anxiety; behavioral /social science research tag; bipolar depression; child behavior disorders; child psychology; clinical research; disease /disorder onset; family genetics; genetic susceptibility; human genetic material tag; human subject; interview; longitudinal human study; mental disorder diagnosis; mental health epidemiology; molecular biology information system; mood disorders

DESCRIPTION (provided by applicant) Bipolar disorder is a severe heritable psychiatric illness affecting 1% of the general population. The age of onset is generally in the late teenage years or early adulthood. Very little is known about specific risk factors that influence the incidence and age of onset of this disorder. In 1988 the NIMH established a Genetics Initiative in bipolar disorder with the goal of identifying susceptibility genes; this collaboration has identified several hundred families with multiple cases of bipolar disorder. As three of the initial collaborating sites (Indiana University, Johns Hopkins University, and Washington University at St Louis) we are now proposing to assess and follow adolescents, ages 12 -18 years, in these and similar families. This "at risk" group will be compared to a matched set of community comparison subjects. Three hundred study subjects and three hundred controls will be studied using established diagnostic instruments (KSADS- PL) for the adolescents and the parents (DIGS). Other instruments to assess behavior, temperament, family environment, and substance use will be employed. DNA will also be collected. The data will be stored in a database developed to facilitate longitudinal studies of clinical variables. Analyses will compare potential risk factors among the high risk group and the controls. Follow-up of the high risk group will begin in the second year of the study. It is hypothesized that three groups will be identified: 1) adolescents with behavioral symptoms or disorders who will manifest early-onset bipolar disorder; 2) adolescents with anxiety symptoms or disorders who will manifest later-onset b polar disorder; and 3) adolescents with minor mood symptoms or disorders who will manifest later-onset unipolar or bipolar disorder. All subjects will be characterized on the three dimensions of behavioral, anxiety, and mood symptoms; intermediate outcomes and major mood diagnoses will be evaluated in relation to baseline dimensional ratings. The ethical implications of this research will be studied by examining the effects of participation and any effect on self-esteem due to high risk status as well as the implications of the collections and potential use of genetic data for prediction of risk within families. Clinical data and DNA will be shared with the scientific community.

描述（由申请人提供）躁郁症是一种严重的遗传性精神病，影响了1％的普通人群。发病年龄通常是在青少年后期或成年初期。关于影响这种疾病发作的发病率和年龄的特定危险因素知之甚少。 1988年，NIMH建立了一项遗传学在躁郁症中的遗传倡议，目的是识别易感基因。这种合作已经确定了数百个患有多种躁郁症的家庭。作为最初的合作网站（印第安纳大学，约翰·霍普金斯大学和圣路易斯华盛顿大学），我们现在建议在这些和类似家庭中评估和关注12-18岁的青少年。将将这个“处于危险”组与一组匹配的社区比较主题进行比较。将使用已建立的诊断工具（KSADS-PL）研究三百个研究对象和三百个对照组，并为青少年和父母（DIGS）研究。还将采用其他评估行为，气质，家庭环境和物质使用的工具。也将收集DNA。数据将存储在开发的数据库中，以促进临床变量的纵向研究。分析将比较高风险组和对照组之间的潜在危险因素。高风险组的随访将从研究的第二年开始。假设将确定三个组：1）具有行为症状或疾病的青少年会表现出早发性躁郁症； 2）患有焦虑症状或疾病的青少年会表现出以后发作的B极性疾病； 3）患有较小情绪症状或疾病的青少年会表现为以后发作的单极或躁郁症。所有受试者将在行为，焦虑和情绪症状的三个维度上进行表征；将根据基线维等级评估中间结果和主要情绪诊断。这项研究的道德含义将通过检查参与的影响以及由于高风险状况而对自尊的影响以及收集和潜在使用遗传数据的含义来预测家庭内部风险的含义。临床数据和DNA将与科学界共享。