Role of cytidine deaminase in (epi)genetic adaptation of the plant immune system

胞苷脱氨酶在植物免疫系统（表观）遗传适应中的作用

• 批准号: 2449363
• 金额: --
• 依托单位: University of Sheffield
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2449363
• 关键词: Role; cytidine; deaminase; epi; genetic

As sessile organisms, plants are masters in adapting to environmental stresses. Recent work from the Ton lab has shown that plants employ epigenetic mechanisms to prime their immune system long-term against potential pests and diseases. This PhD project will study the interplay between epigenetic and genetic mechanisms controlling expression and diversification of resistance (R) genes in the model plant species Arabidopsis thaliana. In particular, the project will focus on the role of the Arabidopsis cytidine deaminase CDA1 in the modulation of epigenetic marks and its impact on genetic diversity. The student will use state-of-the art genetic and molecular techniques, and work in a highly dynamic lab that combines fundamental research with translational research to develop new technologies that benefit sustainable crop protection.

作为无柄生物，植物是适应环境压力的硕士学位。 TON LAB的最新工作表明，植物采用表观遗传机制来长期针对潜在的害虫和疾病的免疫系统。该博士学位项目将研究控制模型植物物种拟南芥中抗性（R）基因多样化的表观遗传机制和遗传机制之间的相互作用。特别是，该项目将重点关注拟南芥二氨基酶CDA1在表观遗传标记的调节中的作用及其对遗传多样性的影响。该学生将使用最先进的遗传和分子技术，并在一个高度动态的实验室中工作，该实验室将基本研究与转化研究结合在一起，以开发有益于可持续作物保护的新技术。