Pulsatile Hemodynamics and Carotid Stenting

脉动血流动力学和颈动脉支架置入术

• 批准号: 6942331
• 负责人: CHRISTOPHER M QUICK
• 金额: $ 14.01万
• 依托单位: TEXAS A&M UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-30 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6942331
• 关键词: angiography; artery; blood vessel prosthesis; carotid artery; clinical research; endarterectomy; hemodynamics; human subject; laboratory rabbit; mathematical model; oscillatory blood flow; patient oriented research; pulse pressure wave; restenosis

DESCRIPTION (provided by applicant): Angioplasty and stenting of the large conductance vessels that supply the brain is a relatively new treatment that may be a viable alternative to carotid endarterectomy. Based on the extensive history of coronary artery stenting, it can be surmised that restenosis will be a key factor limiting the long-term success of carotid arterial stenting. The hemodynamic factors that influence restenosis, especially pulsatile pressure and flow, have received little scrutiny. We hypothesize that the degree of in-stent restenosis is related to pulsatility of pressure and flow. The following four specific aims will address this hypothesis: 1) To measure the degree of restenosis after carotid artery stenting and associated changes in pulsatile blood pressure and flow; 2) To predict with a patient-specific computational model the short and long-term changes in pulsatile pressure and flow after stenting; 3) To compare restenosis in rabbit iliac arteries that are subjected to high and low levels of pulsatile pressure and flow; 4) To compare remodeling factors in chronically stented vessels subjected to high and low levels of pulsatility. Dr. Quick is an engineer who has an extensive background in computational modeling of pulsatile hemodynamics in vascular beds. Funding is sought for a five-year training periodfor Dr. Quick to transition to a career in quantitative vascular biology. This project, addressing the interaction of hemodynamics and vascular biology, is a fundamentally new direction forDr. Quick, yet complements his expertise. Having studied the effect of vascular mechanical properties on oscillatory blood pressure and flow, he can now focus on the effect of oscillatory pressure and flow on vascular mechanical properties. This project represents a natural progression from theoretical tools to study the phenomena of vascular remodeling to the experimental tools to study the mechanisms of remodeling.

描述（由申请人提供）： 供应大脑的大电导容器的血管成形术和支架是一种相对较新的治疗方法，可能是颈动脉内膜切除术的可行替代方法。根据冠状动脉支架的广泛历史，可以推测再狭窄将是限制颈动脉支架长期成功的关键因素。影响再狭窄的血液动力学因素，尤其是搏动压力和流动，几乎没有受到审查。 我们假设内部再狭窄的程度与压力和流动的搏动性有关。以下四个特定目标将解决这一假设：1）测量颈动脉支架后的再狭窄程度以及脉动血压和流动的相关变化； 2）用患者特异性的计算模型预测脉冲压力和支架后流动的短期和长期变化； 3）比较兔动脉的再狭窄，这些动脉受到高水平和低水平的搏动压力和流动； 4）比较持续的脉动较高和低水平的长期支架血管中的重塑因子。 Quick博士是一名工程师，在血管床中脉动血液动力学的计算建模方面具有广泛的背景。为五年的培训期寻求资金，以使Quick博士过渡到定量血管生物学的职业。该项目解决了血液动力学和血管生物学的相互作用，是一个从根本上进行的福克斯方向。快速，却补充了他的专业知识。在研究了血管机械性能对振荡性血压和流动的影响后，他现在可以专注于振荡压力和流动对血管机械性能的影响。该项目代表了从理论工具开始研究血管重塑现象到研究重塑机制的实验工具的自然发展。