Intracranial Stents for Arterial Stenosis

颅内支架治疗动脉狭窄

• 批准号: 6989075
• 负责人: MARC IVOR CHIMOWITZ
• 金额: $ 13.85万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-12-01 至 2009-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6989075
• 关键词: angiography; artery stenosis; blood vessel prosthesis; cardiovascular disorder prevention; cardiovascular disorder risk; cardiovascular disorder therapy; case history; cerebrovascular occlusions; cerebrovascular surgery; clinical research; clinical trials; curriculum; educational resource design /development; experimental designs; human data; human subject; human therapy evaluation; outcomes research; patient /disease registry; patient care management; patient oriented research; patient safety /medical error; restenosis; stroke

DESCRIPTION (provided by applicant): This proposal for a K24 Award is to support the applicant's career in patient-oriented research, mentoring of beginning clinical investigators, and career development. The long-term research goal of the applicant is to lead an NINDS funded Phase III clinical trial comparing intracranial stenting (using a drug-eluting stent) with best medical therapy in patients with symptomatic intracranial arterial stenosis. To accomplish this, the results of the recently completed NINDS funded Warfarin Aspirin Symptomatic Intracranial Disease (WASID) trial (which the applicant led), coupled with the results of studies in this proposal, will be used to design the Phase III trial. The Specific Aims of the research in this proposal are 1) to determine the 30-day, 1- year, and 2-year rates of stroke following intracranial stenting in a new prospective cohort of patients at high risk of stroke in the territory of the stenotic intracranial artery; 2) to establish the minimal benefit of stenting over medical therapy that physicians would require for stenting to become the treatment of choice; 3) to design a Phase I trial in patients with symptomatic intracranial arterial stenosis that will determine the safety of intracranial stenting (with a drug-eluting stent) and the 6 month re-stenosis rate; and 4) to determine optimal risk factor management in patients with intracranial stenosis. The mentoring responsibilities of the applicant will focus on developing the careers of stroke fellows and junior faculty in the multidisciplinary Emory Stroke Center who are committed to careers in patient-oriented research. This mentoring will include developing educational and research curricula for the trainees, helping trainees design research protocols and write grant applications, and assisting trainees with data analysis, writing of manuscripts and assembling a teaching portfolio. Career development of the applicant will involve taking course work in the analytic sciences at the Emory School of Public Health. This will further the applicant's career as a clinical trial list and make him a more effective mentor. The K24 Award will provide the applicant with the necessary protected time for this period of intensive focus on research and mentoring. This will help him achieve his career goals of making important contributions to the field of stroke therapeutics and training the next generation of patient-oriented stroke investigators.

描述（由申请人提供）：本 K24 奖提案旨在支持申请人在以患者为导向的研究、指导初级临床研究人员和职业发展方面的职业生涯。申请人的长期研究目标是领导一项 NINDS 资助的 III 期临床试验，比较颅内支架置入术（使用药物洗脱支架）与有症状颅内动脉狭窄患者的最佳药物治疗。为了实现这一目标，最近完成的 NINDS 资助的华法林阿司匹林症状性颅内疾病 (WASID) 试验（由申请人领导）的结果，加上本提案中的研究结果，将用于设计 III 期试验。本提案中研究的具体目标是 1) 确定在美国境内脑卒中高风险患者的新前瞻性队列中颅内支架置入后 30 天、1 年和 2 年的脑卒中发生率颅内动脉狭窄； 2) 确定支架置入术相对于药物治疗的最小益处，医生要求支架置入术成为首选治​​疗方法； 3）针对有症状的颅内动脉狭窄患者设计一项I期试验，以确定颅内支架置入（使用药物洗脱支架）的安全性和6个月的再狭窄率； 4) 确定颅内狭窄患者的最佳危险因素管理。申请人的指导职责将侧重于发展多学科埃默里中风中心的中风研究员和初级教员的职业生涯，他们致力于以患者为导向的研究职业。这种指导将包括为学员开发教育和研究课程，帮助学员设计研究方案和撰写资助申请，并协助学员进行数据分析、撰写手稿和组建教学作品集。申请人的职业发展将涉及在埃默里公共卫生学院学习分析科学课程。这将进一步推动申请人作为临床试验名单的职业生涯，并使他成为更有效的导师。 K24 奖将为申请人提供必要的受保护时间，以供其集中精力进行研究和指导。这将帮助他实现为中风治疗领域做出重要贡献并培训下一代以患者为中心的中风研究人员的职业目标。