PSYCHOPATHOLOGY IN YOUNG PEOPLE WITH MENTAL RETARDATION

智力低下年轻人的心理病理学

• 批准号: 6875316
• 负责人: SCOTT M. HOFER
• 金额: $ 23.03万
• 依托单位: PENNSYLVANIA STATE UNIVERSITY, THE
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-04-01 至 2008-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6875316
• 关键词: Downs syndrome; Prader Willi syndrome; Williams syndrome; adolescence (12-20); autism; behavior disorders; behavioral /social science research tag; child (0-11); clinical research; developmental psychology; family structure /dynamics; fragile X syndromes; human data; international cooperation; interview; longitudinal human study; mental health; mental health epidemiology; mental retardation; mood disorders; pathologic process; psychometrics; psychopathology; questionnaires; social psychology; social support network; young adult human (21-34)

DESCRIPTION (provided by applicant): The purpose of this application is to support an ongoing program of research aimed at determining risk and resilience factors in the evolution of psychopathology in an internationally unique cohort of young people with mental retardation that forms the Australian Child to Adult Development (ACAD) Study. The broad aims of this application are to 1) study the course and pattern of psychopathology in children with mental retardation; 2) examine potential biopsychosocial risk and protective factors which may be associated with psychopathology; and 3) evaluate and refine the measurement properties of the DEC, the principal instrument used to assess psychopathology in this study and in broad use internationally. The fourth wave of the ACAD study (14 years of follow-up) has now been completed and permits analysis of the development of psychopathology from childhood through adolescence to young adulthood. Advanced statistical methods, including growth mixture models, will be used to identify developmental trajectories of emotional and behavioral disturbance in these groups, to investigate risk, mediating and moderating factors, and to empirically delineate subpopulations showing distinct patterns of change over time. A separate aim is to evaluate and refine the psychometric properties of the Developmental Behavioral Checklist (DEC) in the longitudinal ACAD study and in several international cross-sectional datasets. The analysis of psychometric properties of the DEC will use new developments for multiple-group factor analysis of categorical data and item-response models to construct and evaluate a short-form measure of psychopathology. This application provides an extraordinary opportunity to evaluate the mental health pathway of this vulnerable population through the transition into adulthood. The unifying purpose of this project is to apply advanced statistical modeling techniques to the existing ACAD data and to strengthen the findings by incorporating comparable data collected in a number of other countries.

描述（由申请人提供）：本申请的目的是支持正在进行的研究计划，旨在在国际独特的年轻人中，旨在确定心理病理学进化的风险和韧性因素，这些年轻人构成了澳大利亚儿童对成人发展（ACAD）研究的构成。本应用的广泛目的是1）研究心理迟缓儿童的心理病理学课程和模式； 2）检查可能与心理病理学有关的潜在生物心理社会风险和保护因素； 3）评估和完善DEC的测量特性，即在本研究中以及在国际上广泛使用中用于评估心理病理学的主要工具。 该学院研究的第四波浪潮（随访14年）现已完成，并允许对从童年到青春期到年轻成年的精神病理学发展进行分析。包括生长混合模型在内的先进统计方法将用于识别这些群体中情绪和行为干扰的发育轨迹，以调查风险，调解和调节因素，并经验描绘的亚群显示出随时间变化的不同模式。一个单独的目的是评估和完善纵向学院研究和几个国际横截面数据集中发展行为清单（DEC）的心理测量特性。对DEC的心理测量特性的分析将使用新的发展来对分类数据和项目响应模型进行多组因子分析，以构建和评估精神病学的简短量度。 该应用程序提供了一个非凡的机会，可以通过过渡到成年后评估这一脆弱人群的心理健康路径。该项目的统一目的是将高级统计建模技术应用于现有的ACAD数据，并通过合并在许多其他国家 /地区收集的可比数据来加强发现。