PSYCHOPATHOLOGY IN YOUNG PEOPLE WITH MENTAL RETARDATION

智力低下年轻人的心理病理学

• 批准号: 7301146
• 负责人: SCOTT M. HOFER
• 金额: $ 11.07万
• 依托单位: OREGON STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-04-01 至 2008-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7301146
• 关键词: Downs syndrome; Prader Willi syndrome; Williams syndrome; adolescence (12-20); autism; behavior disorders; behavioral /social science research tag; child (0-11); clinical research; developmental psychology; family structure /dynamics; fragile X syndromes; human data; international cooperation; interview; longitudinal human study; mental health; mental health epidemiology; mental retardation; mood disorders; pathologic process; psychometrics; psychopathology; questionnaires; social psychology; social support network; young adult human (21-34)

DESCRIPTION (provided by applicant): The purpose of this application is to support an ongoing program of research aimed at determining risk and resilience factors in the evolution of psychopathology in an internationally unique cohort of young people with mental retardation that forms the Australian Child to Adult Development (ACAD) Study. The broad aims of this application are to 1) study the course and pattern of psychopathology in children with mental retardation; 2) examine potential biopsychosocial risk and protective factors which may be associated with psychopathology; and 3) evaluate and refine the measurement properties of the DEC, the principal instrument used to assess psychopathology in this study and in broad use internationally. The fourth wave of the ACAD study (14 years of follow-up) has now been completed and permits analysis of the development of psychopathology from childhood through adolescence to young adulthood. Advanced statistical methods, including growth mixture models, will be used to identify developmental trajectories of emotional and behavioral disturbance in these groups, to investigate risk, mediating and moderating factors, and to empirically delineate subpopulations showing distinct patterns of change over time. A separate aim is to evaluate and refine the psychometric properties of the Developmental Behavioral Checklist (DEC) in the longitudinal ACAD study and in several international cross-sectional datasets. The analysis of psychometric properties of the DEC will use new developments for multiple-group factor analysis of categorical data and item-response models to construct and evaluate a short-form measure of psychopathology. This application provides an extraordinary opportunity to evaluate the mental health pathway of this vulnerable population through the transition into adulthood. The unifying purpose of this project is to apply advanced statistical modeling techniques to the existing ACAD data and to strengthen the findings by incorporating comparable data collected in a number of other countries.

描述（由申请人提供）：本申请的目的是支持一项正在进行的研究计划，旨在确定国际上独特的智障年轻人群体中精神病理学演变的风险和复原力因素，该群体形成了澳大利亚儿童到成人的群体发展（ACAD）研究。该应用程序的主要目标是 1) 研究智力低下儿童的精神病理学过程和模式； 2）检查可能与精神病理学相关的潜在生物心理社会风险和保护因素； 3) 评估和完善 DEC 的测量特性，DEC 是本研究中用于评估精神病理学的主要工具，并在国际上广泛使用。 ACAD 第四波研究（14 年的随访）现已完成，可以分析从儿童期到青春期再到成年早期的精神病理学发展。包括生长混合模型在内的先进统计方法将用于确定这些群体情绪和行为障碍的发展轨迹，调查风险、中介和调节因素，并凭经验描绘随时间变化的不同模式的亚群。另一个目标是在纵向 ACAD 研究和几个国际横截面数据集中评估和完善发展行为检查表 (DEC) 的心理测量特性。 DEC 的心理测量特性分析将使用分类数据的多组因素分析和项目反应模型的新发展来构建和评估精神病理学的简短形式测量。 该应用程序提供了一个绝佳的机会来评估这一弱势群体向成年过渡的心理健康途径。该项目的统一目的是将先进的统计建模技术应用于现有的 ACAD 数据，并通过纳入在许多其他国家收集的可比数据来加强研究结果。