How does the plant decode self- and non-self-signals to balance immune response and growth?

植物如何解码自体和非自体信号以平衡免疫反应和生长？

• 批准号: 2444970
• 金额: --
• 依托单位: University of East Anglia
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2444970
• 关键词: How; does; plant; decode; self

Plants sense microbial pathogens through the detection of pathogen associated molecular patterns (PAMP) and this is mediated by cell surface localised pattern recognition receptors (PRR). Perception of PAMPs triggers a signaling network that includes activation of mitogen activated protein kinases (MAPK), activation of defense gene expression and ultimately leads to PAMP triggered immunity (PTI). What connects activated PRRs to downstream MAPKs has remained elusive. We have identified potential candidate phospho-proteins that could bridge the gap in our understanding of PRR signaling. In the current project the receptor based signaling event will be studied with advanced proteomics approaches, molecular genetics approaches and cell biology (using confocal microscopy). The project will also involve significant protein biochemistry.

植物通过检测病原体相关分子模式 (PAMP) 来感知微生物病原体，这是由细胞表面局部模式识别受体 (PRR) 介导的。对 PAMP 的感知会触发信号网络，包括丝裂原激活蛋白激酶 (MAPK) 的激活、防御基因表达的激活，并最终导致 PAMP 触发免疫 (PTI)。激活的 PRR 与下游 MAPK 之间的联系仍不清楚。我们已经确定了潜在的候选磷酸蛋白，可以弥补我们对 PRR 信号传导理解的空白。在当前的项目中，将利用先进的蛋白质组学方法、分子遗传学方法和细胞生物学（使用共聚焦显微镜）研究基于受体的信号传导事件。该项目还将涉及重要的蛋白质生物化学。