Bringing Molecular Contrast to OCT

将分子对比引入 OCT

• 批准号: 6951079
• 负责人: Brian E. Applegate
• 金额: $ 5.05万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-01 至 2006-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6951079
• 关键词: Halobacteriaceae; bacteriorhodopsins; bioimaging /biomedical imaging; contrast media; fluorescent dye /probe; imaging /visualization /scanning; indocyanine green; molecular probes; optical tomography; photonics; postdoctoral investigator; spectrometry

DESCRIPTION (provided by applicant): Optical coherence tomography has superior depth penetration, comparable spatial resolution, and superior temporal resolution than any other optical imaging technique, however it lacks the ability to utilize molecular contrast that other optical imaging modalities possess. Molecular contrast provides these techniques with the ability to enhance the contrast of particular tissue morphologies by the administration of contrast agents. It also enables them to record the time evolution of contrast agent concentration, a property extremely useful for drug development and discovery, developmental biology, and clinical diagnostics. We intend to couple proven nonlinear spectroscopic techniques to optical coherence tomography, in order to provide molecular contrast.

描述（由申请人提供）：光学连贯性层析成像具有优越的深度穿透力，可比的空间分辨率和较高的时间分辨率，而不是任何其他光学成像技术，但是它缺乏使用其他光学成像模式所具有的分子对比的能力。分子对比提供了这些技术，具有通过施用造影剂来增强特定组织形态的对比度的能力。它还使他们能够记录造影剂浓度的时间演变，这是一种对药物开发和发现，发育生物学和临床诊断非常有用的特性。我们打算将经过证明的非线性光谱技术与光学相干断层扫描相结合，以提供分子对比度。

项目成果

Theoretical comparison of the sensitivity of molecular contrast optical coherence tomography techniques.

分子对比光学相干断层扫描技术灵敏度的理论比较。

• DOI: 10.1364/opex.13.008146
• 发表时间: 2005
• 期刊: Optics express
• 影响因子: 3.8
• 作者: Applegate,Brian;Yang,Changhuei;Izatt,Joseph
• 通讯作者: Izatt,Joseph