X-ray imaging using edge-on-microchannel plate detectors

使用边缘微通道板探测器进行 X 射线成像

• 批准号: 6884583
• 负责人: SABEE MOLLOI
• 金额: $ 23.94万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-07-01 至 2007-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6884583
• 关键词: X ray; bioengineering /biomedical engineering; bioimaging /biomedical imaging; biomedical equipment development; calcification; charge coupled device camera; computed axial tomography; computer program /software; electromagnetic radiation; image enhancement; imaging /visualization /scanning; mammography; monitoring device; radiation dosage; radiography; radiology

DESCRIPTION (provided by applicant): A diagnostic X-ray imaging system is required to simultaneously have high contrast, high resolution and be fast with low dose to the patient. High contrast and low dose requirements are of a particular interest in mammography, where low contrast tumors and microcalcifications are to be detected at high scatter levels. The limitations of the currently scanning slot systems include the inherently high noise level of the CCD, suboptimal conversion efficiency, limited charge capacity of the CCD and its relatively high scatter fraction (up to 20%) due to its wide scanning slot. The purpose of this project is to develop a scanning multi-slit X-ray imaging system based on an "edge-on" illuminated microchannel plate (MCP) detector for potential application in mammography. The advantages of an "edge-on" MCP detector over other types of X-ray detectors are the possibility to combine high stopping power, superior spatial resolution, direct energy-tocharge conversion, high physical charge amplification and very low noise. More specifically, the aims are: (1) Design and development of a scanning slit X-ray imaging system based on "edge-on" MCP detector and delay line electronics for digital mammography. (2) Investigation of the hypothesis that an X-ray imaging system based on "edge-on" MCP detector can offer substantially improved detection quantum efficiency, resolution, noise and scatter fraction as compared to other currently available mammography systems. (3) Design and development of chip level application specific integrated circuit (ASIC) electronics with very highcount rate capability. (4) Development and evaluation of a clinically applicable single slit prototype X-ray imaging system based on "edge-on" MCP detector with ASIC electronics. (5) Design of a clinically applicable multi-slit x-ray imaging system for digital mammography. The proposed multi-slit X-ray imaging system based on an "edge-on" MCP detector will be photon counting, quantum limited and low scatter fraction. It can potentially provide a high-resolution detector with significant reduction in patient dose for digital mammography.

描述（由申请人提供）： 需要诊断X射线成像系统同时具有高对比度，高分辨率，并且对患者的剂量低剂量。高对比度和低剂量需求在乳房X线摄影中特别感兴趣，在高散射水平上将检测到低对比度肿瘤和微钙化。当前扫描插槽系统的局限性包括CCD的固有高噪声水平，次优的转换效率，CCD的有限电荷能力以及其相对较高的散射分数（高达20％），这是由于其较宽的扫描插槽。该项目的目的是开发基于“边缘”照明微通道板（MCP）检测器的扫描多缝X射线成像系统，以在乳房X线摄影中使用。与其他类型的X射线检测器相比，“边缘” MCP检测器的优点可能是结合高停止功率，高级空间分辨率，直接电荷转换，高物理电荷放大和非常低的噪声。更具体地说，目的是：（1）基于“ Edge-On” MCP检测器和用于数字乳房X线摄影的“ Edge-On” MCP检测器的设计和开发。 （2）研究基于“边缘” MCP检测器的X射线成像系统可以提供的假设可提供与其他当前可用的乳房X线摄影系统相比，可提供可提供的检测量效率，分辨率，噪声和散射分数。 （3）具有非常高率速率能力的芯片级应用特定集成电路（ASIC）电子设备的设计和开发。 （4）基于ASIC电子设备的“边缘” MCP检测器的临床适用的单缝原型X射线成像系统的开发和评估。 （5）设计用于数字乳房X线摄影的临床适用的多缝X射线成像系统。基于“边缘” MCP检测器的拟议的多缝X射线成像系统将是光子计数，量子限制和低散射分数。它可能会提供高分辨率检测器，以显着减少数字乳房摄影的患者剂量。