Gender & Symptom Differences in Acute Coronary Syndromes

性别

• 批准号: 6754802
• 负责人: HOLLI A DEVON
• 金额: $ 13.3万
• 依托单位: MARQUETTE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-05-01 至 2005-08-12
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6754802
• 关键词: age difference; angina pectoris; anxiety; behavior test; cardiovascular disorder risk; clinical research; diabetes mellitus; functional ability; gender difference; health disparity; heart disorder diagnosis; hospital utilization; human subject; interview; medical records; mood disorders; myocardial infarction; patient oriented research; socioenvironment; syndrome

DESCRIPTION (provided by applicant): Heart disease is the foremost public health issue in the United States for both women and men. Diabetes and obesity, twin epidemics and major risk factors for heart disease, have increased 61% and 74% respectively in only 10 years. Furthermore, in every year since 1984, more women than men have died from cardiovascular disease. Therefore, the purpose of this study is to determine if there are gender and/or symptom differences in acute coronary syndromes (ACS) and to determine if differences persist after controlling for age, diabetes mellitus, functional status, and mood. ACS includes three clinical diagnoses: unstable angina, non-ST elevation myocardial infarction (MI), and ST-elevation MI. Gender similarities and differences will be identified in each diagnostic group as well as for ACS as a whole. In addition, comparison of symptoms will be made between the three diagnostic groups. Specific aims include: (1) to identify the type, severity, location, and quality of the symptoms of ACS for women and men admitted to the hospital; (2) to assess functional status in the week prior to hospitalization: (3) to examine levels of anxiety and depression prior to hospitalization; and (4) to describe risk factors, health history, and socio-demographic differences between women and men. This descriptive, comparative study will include a non-probability sample of approximately 110 women and 110 men, hospitalized with ACS. Four metropolitan midwestern sites will be sampled in order to increase the likelihood of enrolling a heterogeneous sample encompassing a broad array of racial and ethnic groups, income levels, and cultures. At least one third of the sample will come from minority groups. Subjects will be interviewed in their hospital room a minimum of 12 hours after admission. The Symptoms of Acute Coronary Syndromes Inventory, The Canadian Cardiovascular Society classification of angina tool, and the Hospital Anxiety and Depression Scale will be used to collect data. Results of this study will provide a basis for; (1) development of gender- based models of symptoms for ACS that can be disseminated to the public, those with established coronary heart disease (CHD), and to practitioners who evaluate patients with possible ACS; (2) development and testing of a Symptoms of ACS assessment tool that can be used by paramedics and triage nurses; and (3) development and testing interventions that will inform women of their vulnerability to CHD.

描述（由申请人提供）：心脏病是美国男女最重要的公共卫生问题。糖尿病和肥胖，双流行病和心脏病的主要危险因素分别增加了10年，分别增加了61％和74％。此外，自1984年以来，每年的女性都多于男性死于心血管疾病。因此，这项研究的目的是确定急性冠状动脉综合征（AC）是否存在性别和/或症状差异，并确定在控制年龄，糖尿病，糖尿病，功能状态和情绪之后是否存在差异。 ACS包括三个临床诊断：不稳定的心绞痛，非ST升高心肌梗塞（MI）和ST-Elevation MI。在每个诊断组以及整个ACS中，都将确定性别的相似性和差异。 另外，将在三个诊断组之间进行症状的比较。具体目的包括：（1）确定送往医院的男女AC症状的类型，严重性，位置和质量； （2）在住院前一周评估功能状况：（3）在住院前检查焦虑和抑郁水平； （4）描述男女之间的风险因素，健康病史和社会人口统计学差异。这项描述性的比较研究将包括大约110名女性和110名男性的非概率样本，并被ACS住院。将对四个大都市中西部地点进行采样，以增加参加各种种族和种族群体，收入水平和文化的异质样本的可能性。至少三分之一的样本将来自少数群体。入院后至少12小时，将在他们的病房接受对象进行采访。急性冠状动脉综合征库存，加拿大心血管社会工具的分类以及医院焦虑和抑郁量表的症状将用于收集数据。这项研究的结果将为； （1）开发可将AC的基于性别的症状模型开发，这些模型可以传播给公众，患有冠心病（CHD）的人，以及评估ACS患者的从业者； （2）使用护理人员和分类护士可以使用的ACS评估工具的症状的开发和测试； （3）开发和测试干预措施，这些干预措施将为妇女提供脆弱性。