GENDER DIFFERENCES IN THE SYMPTOMS OF UNSTABLE ANGINA

不稳定型心绞痛症状的性别差异

• 批准号: 6402814
• 负责人: HOLLI A DEVON
• 金额: $ 1.77万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-29 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6402814
• 关键词: angina pectoris; clinical research; female; gender difference; heart disorder diagnosis; human subject; male; sign /symptom; women's health

The objective of this proposal is to determine if there are gender differences in the symptoms of unstable angina, which are not explained by age, diabetes, or mood. A descriptive, quantitative study design will be used to identify the symptoms experienced prior to admission to the hospital for an acute episode of unstable angina. Forty-five females and forty-five males will be interviewed. An open-ended question will be used to assess the patients' symptom experience in their own words. Instruments measuring type, location, and severity of symptoms, mood, and baseline characteristics will be used to identify and explicate the symptom experience. The description of symptoms is the mechanism by which patients gain entry to the health care system. In the acute setting, the descriptors used may affect triage in the emergency department, the use of cardiac interventions, and the course of treatment. The symptoms of a heart attack and/or unstable angina listed by the American Heart Association (AHA) and accepted by practitioners have previously been based on a male model and may not be applicable to women. Recent studies, which have included women, suggest that there may be gender differences in the symptoms experienced with both acute myocardial infarction (AMI) and unstable angina. The majority of these studies have included only patients diagnosed with AMI. Because CHD in women is primarily manifested by angina and not AMI, many women have been excluded from analysis. This study will examine patients diagnosed with unstable angina in order to gather data that has been heretofore lacking in women.

该提案的目的是确定不稳定心绞痛的症状是否存在性别差异，而这些症状并未通过年龄，糖尿病或情绪来解释。描述性的定量研究设计将用于识别入院前急性心绞痛发作之前所经历的症状。将采访四十五名女性和四十五名男性。开放式问题将用来用自己的话来评估患者的症状经历。测量症状，情绪和基线特征的类型，位置和严重程度的仪器将用于识别和阐明症状体验。症状的描述是患者进入医疗保健系统的机制。在急性环境中，所使用的描述符可能会影响急诊科中的分类，使用心脏干预和治疗过程。美国心脏协会（AHA）列出并被从业者接受的心脏病发作和/或不稳定的心绞痛的症状以前是基于男性模型，可能不适用于女性。最近的研究包括女性，表明急性心肌梗塞（AMI）和不稳定的心绞痛的症状可能存在性别差异。这些研究中的大多数仅包括被诊断为AMI的患者。由于女性中的CHD主要由心绞痛而不是AMI表现出来，因此许多女性被排除在分析之外。这项研究将检查被诊断出患有不稳定心绞痛的患者，以收集迄今为止缺乏女性的数据。