PAIN AND BETA-ENDORPHIN RESPONSES IN MEN AND WOMEN

男性和女性的疼痛和 β-内啡肽反应

• 批准号: 6184766
• 负责人: DAVID C SHEFFIELD
• 金额: $ 23.12万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-30 至 2002-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6184766
• 关键词: adenosine; angina pectoris; behavioral /social science research tag; blood pressure; clinical research; coronary disorder; endorphins; female; gender difference; heart rate; heat stimulus; human subject; imagery; ischemia; male; naloxone; neural information processing; pain; pain threshold; physiologic stressor; psychophysiology

DESCRIPTION (adapted from investigator's abstract): Much epidemiological, clinical, and experimental data attests to a relationship between gender and the perception of painful stimuli: women have greater pain sensitivity than men. In this research, the question is raised as to whether differences in opioid peptide responses are responsible, at least in part, for these gender differences. The investigators will examine gender differences in pain sensitivity in patients with stable angina, and in individuals without evidence of coronary artery disease and no chest pain. The following specific aims will be tested: (1) Women will exhibit greater sensitivity to thermal, ischemic, and cold pressor pain than men, and in men, but not women, pain sensitivity will be inversely related to plasma beta-endorphin levels; (2) Induction of chest pain by adenosine will be attenuated by beta-endorphin infusion in men, but not women, this effect will be reversed by naloxone; (3) Use of a cognitive strategy (imagery) will attenuate pain sensitivity, as indexed by tolerance and threshold to ischemic pain and time to onset of angina during exercise testing, to a greater extent in men and will be reversed by naloxone. In Study 1, 200 subjects will undergo cold pressor, forearm ischemia, and thermal pain tests in randomized order. Blood pressure, heart rate and plasma beta-endorphin levels will be determined to assess whether they mediate pain perception differently in men and women. In Study 2, the investigators plan to examine whether plasma beta-endorphin levels attenuate adenosine-provoked chest pain to a greater extent in men than women. The dose-effect curve for pain provoked by adenosine will be established for 40 subjects. Beta-endorphin, and later naloxone, will then be infused and a new dose-effect curve for adenosine-provoked chest pain will be established. In Study 3, they will examine whether cognitive coping strategies attenuate pain differently in men and women. 200 subjects will be assigned to one of two conditions: control and imagery task. Subjects will undergo an exercise test and forearm ischemia test in random order. Blood pressure, heart rate and plasma beta-endorphin levels will be determined to assess whether they mediate pain sensitivity differently in men and women. Finally, naloxone will be introduced to determine if thee effects are mediated by beta-endorphin.

描述（根据研究者的摘要改编）：很多流行病学， 临床，实验数据证明了性别与 对疼痛刺激的感知：女性比 男人。在这项研究中，提出了一个问题，即是否有差异 阿片类肽反应至少部分是因为这些性别 差异。调查人员将检查疼痛的性别差异 稳定心绞痛的患者以及没有证据的个体的敏感性 冠状动脉疾病和无胸痛。以下具体目标将 接受测试：（1）女性对热，缺血和 冷压痛比男人和男性，但女性疼痛，疼痛敏感性将是 与等离子体β-内啡肽水平成反比； （2）诱发胸痛 腺苷将被男性β-内啡肽输液减弱，但不会 妇女，这种影响将被纳洛酮逆转。 （3）使用认知 策略（图像）将减弱疼痛的敏感性，如宽容和 在运动测试期间，缺血性疼痛的阈值和心绞痛发作的时间， 在男性中，纳洛酮在更大程度上会逆转。 在研究1中，有200名受试者将受到冷压力，前臂缺血和 热疼痛测试以随机顺序进行。血压，心率和血浆 将确定β-内啡肽水平以评估它们是否介导疼痛 男人和女人的感知不同。在研究2中，研究人员计划 检查血浆β-内啡肽水平是否衰减腺苷的胸部 男性的疼痛比女人更大。疼痛的剂量效应曲线 将为40名受试者建立腺苷引起的。 beta-endorphin和 后来的纳洛酮将被注入，并为新的剂量效应曲线 将建立发挥腺苷的胸痛。在研究3中，他们将 检查认知应对策略是否对男性的疼痛减轻了不同 和女人。 200个受试者将被分配给两个条件之一：控制和 图像任务。受试者将接受运动测试和前臂缺血测试 以随机顺序。血压，心率和血浆β-内啡肽水平 将确定评估它们是否以不同的方式介导疼痛敏感性 在男人和女人中。最后，将引入纳洛酮以确定您是否是您的 效果由β-内啡肽介导。