Effects of Traditional Acupuncture on Mechanisms of CHD

传统针灸对冠心病机制的影响

• 批准号: 7493755
• 负责人: Cathleen Noel Bairey Merz
• 金额: $ 57.76万
• 依托单位: CEDARS-SINAI MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-01 至 2010-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7493755
• 关键词: Accounting; Acupuncture procedure; Acute; Angina Pectoris; Animal Model; Anxiety; Arrhythmia; Arteries; Autonomic nervous system; Blinded; Blood Pressure; Blood Vessels; C-reactive protein; Cardiac; Cardiac Death; Cardiovascular system; Cause of Death; Cessation of life; Complement; Complementary Medicine; Complementary and alternative medicine; Constriction procedure; Control Groups; Controlled Study; Coronary heart disease; Data; Disease; Doctor of Medicine; Equipment and supply inventories; Etiology; Event; Frequencies; Functional disorder; Health Care Costs; Heart Rate; Hemostatic Agents; Holter Electrocardiography; Hostility; Hyperlipidemia; Hypertension; Infarction; Inflammation; Inflammatory; Intervention; Investigation; Measures; Mediating; Medical; Mental Depression; Myocardial Infarction; Myocardial Ischemia; Nervous system structure; Nitric Oxide; Outcome; Parasympathetic Nervous System; Patients; Physiological; Prevention; Production; Psyche structure; Psychological Stress; Psychosocial Stress; Quality of life; Questionnaires; Randomized; Randomized Controlled Trials; Recurrence; Research Personnel; Risk Factors; Role; Scandinavian; Simvastatin; Social support; Stress; Sudden Death; Sympathetic Nervous System; Symptoms; System; Techniques; Testing; Tobacco use; Ultrasonography; Vasomotor; Work; blood lipoprotein; brachial artery; disability; functional status; hemodynamics; improved; programs; psychologic; size; sudden cardiac death; vasomotion

DESCRIPTION (provided by applicant): Coronary heart disease in the leading cause of death, disability, and health care costs in the US. Among patients with established coronary heart disease (CHD), a majority of patients continue to have acute cardiac events, many sudden and unexpected, despite identification and treatment of their disease and traditional risk factors. Substantial evidence indicates that psychosocial stress and the sympathetic nervous system contributes to acute cardiac events. Preliminary evidence suggests that complementary medicine practices, such as traditional acupuncture (TA), may beneficially alter outcomes in patients with CHD, although the mechanisms responsible for the observed benefit are unknown. We propose to conduct a randomized, blinded, controlled study of the effects of the complementary medicine practice of traditional acupuncture (TA) compared to sham TA and waiting control group on the primary outcome of: 1) autonomic nervous system imbalance (heart rate variability); and the secondary outcomes of: 2) an inflammatory marker (high-sensitivity C reactive protein); and 3) psychological stress, depression, hostility, anxiety, social support, and quality of life; and the exploratory variable of arterial vasomotion (brachial artery reactivity testing). We hypothesize that the complementary medicine practice of TA can serve as an additive/alternative treatment for the prevention of acute cardiac events in CHD patients. The results of this randomized controlled trial will: a) yield new data regarding the pathophysiologic mechanisms effected by the complementary medicine practice of TA in CHD patients, and b) provide pilot data for a large multi-center study of the effect of TA on acute CHD events, including sudden cardiac death.

描述（由申请人提供）：美国主要的死亡，残疾和医疗保健费用的冠状动脉心脏病。在已建立冠心病（CHD）的患者中，尽管鉴定和治疗其疾病和传统危险因素，但大多数患者仍有急性心脏事件，许多突然而出乎意料的事件。大量证据表明，社会心理压力和交感神经系统有助于急性心脏事件。初步证据表明，诸如传统针灸（TA）之类的补充医学实践可能会有益地改变CHD患者的结局，尽管造成观察到的益处的机制尚不清楚。 我们建议与假TA和等待对照组相比，对传统针灸（TA）的互补医学实践的影响进行随机，盲目的对照研究：1）自主神经系统失衡（心率变异）；以及：2）炎症标记（高敏化C反应性蛋白）的次要结果； 3）心理压力，抑郁，敌对，焦虑，社会支持和生活质量；和动脉血管舒张症的探索性变量（臂动脉反应性测试）。我们假设TA的互补医学实践可以作为预防CHD患者急性心脏事件的添加/替代方法。 这项随机对照试验的结果将：a）产生有关CHD患者TA互补医学实践所产生的病理生理机制的新数据，b）为大量多中心研究提供了对TA对TA对急性CHD事件的影响的大量多中心研究，包括心脏突然死亡。