Airborne Nanoparticles for Therapeutic Applications

用于治疗应用的气载纳米颗粒

• 批准号: 6740578
• 负责人: AMIR A NAQWI
• 金额: $ 20万
• 依托单位: POWERSCOPE, INC
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6740578
• 关键词: adenocarcinoma; biomedical equipment; biomedical equipment development; drug delivery systems; electric field; electrical conductance; fluidity; high throughput technology; inhalation drug administration; laboratory mouse; laboratory rabbit; lung neoplasms; molecular size; nanotechnology; neoplasm /cancer chemotherapy; particle accelerators; proliferative vitreoretinopathy; respiratory therapy; retina detachment; surface property

DESCRIPTION (provided by applicant): A device for generating airborne particles in the size range 20-100 nm at the rate of micrograms per minute is proposed. This particle generator will utilize multiple heads of multi-jet electrosprays to obtain the desired throughput of the particulate matter. The proposed nanoparticle generator will be used to deliver certain potent drugs to animal models. The first set of animal experiments will involve delivery of drug nanoparticles to the lungs through inhalation. Particle deposition efficiencies in various parts of the animal lungs will be studied and efficacy of the candidate drugs in treating adenocarcinomas (cancer of the deep lung) will be examined. In a second set of animal experiments, the drug nanoparticles will be suspended in a perfluorocarbon gas bubble used to occlude and tamponade retinal breaks and tears. The drug composition in this application is intended to inhibit the proliferative vitreoratinopathy (re-detachment of the retina in the presence of a scar tissue). Tests will be designed to study the efficacy of the drugs in this respect. Effectiveness of the proposed technique in generating airborne suspensions of macromolecules will be examined. We will also study the feasibility of scaling up the throughput of the above device to milligrams per minute.

描述（由申请人提供）：提出了一种以每分钟微克速度为20-100 nm的空气颗粒的设备。该粒子发生器将利用多喷射电喷雾的多个头部获得颗粒物的所需吞吐量。拟议的纳米颗粒发生器将用于向动物模型输送某些有效的药物。第一组动物实验将涉及通过吸入将药物纳米颗粒递送到肺部。将研究动物肺部各个部位的颗粒沉积效率，并将检查候选药物治疗腺癌（深肺癌）的功效。在第二组动物实验中，该药物纳米颗粒将悬浮在用于阻塞和润肤性视网膜断裂和泪水的全氟化合物气泡中。该应用中的药物组成旨在抑制增生性玻璃体病（在存在疤痕组织的情况下重新探索视网膜）。测试将旨在研究这方面的药物的功效。将检查所提出的技术在产生大分子的空气传播悬浮液方面的有效性。我们还将研究将上述设备吞吐量到每分钟毫克的可行性。