Biostatistics

生物统计学

基本信息

批准号：
8377247
负责人：
Elizabeth Garrett-Mayer
金额：
$ 13.44万
依托单位：
MEDICAL UNIVERSITY OF SOUTH CAROLINA
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/8377247
关键词：
Applications Grants Basic Science Biometry Biostatistics Shared Resource Calendar Cancer Center Cancer Center Support Grant Cancer Control Cancer Patient Clinical Clinical Trials Collaborations Consultations Data Data Analyses Development Education Ensure Faculty Goals Grant Individual Journals Malignant Neoplasms Manuscripts Medical Methodology Mission Monitor NCI Center for Cancer Research Outcome Patients Phase Pilot Projects Play Postdoctoral Fellow Preparation Productivity Proteomics Protocols documentation Publications Randomized Clinical Trials Reporting Research Research Design Research Personnel Resource Sharing Role Safety Sample Size Services South Carolina Statistical Methods United States National Institutes of Health Universities Validity and Reliability abstracting anticancer research base burden of illness cancer prevention cost effective design expectation improved interest lectures member novel population based prevent programs protocol development web site

项目摘要

The Biostatistics Shared Resource (BSR) provides statistical support and services to the Hollings Cancer Center (HCC) investigators. Specific services include assistance with grant and trial development, data analysis, clinical trial review and monitoring and education. For grant and protocol development, the BSR nelps HCC investigators by assisting with defining aims and outcomes, selecting an appropriate study design, developing a statistical analysis plan, and performing sample size calculations to determine and justify the number of subjects or patients included in the study. The HCC BSR also actively assists with data analysis in a number of settings, including manuscript and abstract preparation, preliminary data for grant submissions, and for pilot projects supported by HCC. The faculty of the BSR participates in the HCC Protocol Review and Data and Safety Monitoring Committees providing critical review of trials and in providing educational opportunities to faculty, fellows, residents and staff of the HCC. There are currently four statisticians in the BSR. The BSR has provided services to all four HCC research programs presented in this application and to a developing program in cancer prevention and control. Since the new BSR Director was appointed in February 2007, usage of the BSR has increased dramatically. Thirty-seven grants have been submitted in the previous calendar year, and 27 manuscripts and abstracts submitted with the support of the BSR. These efforts demonstrate the current high utilization of the BSR by HCC investigators, and a strong commitment of the BSR to the research goals of the HCC. The specific purposes of the BSR are to: Collaborate with HCC investigators in study development, implementation, and publication by providing assistance with study design, statistical analysis plans, sample size considerations, statistical analysis, and grant and manuscript preparation Utilize, adapt and develop novel statistical methodologies, as needs arise, to respond to challenging research issues in ongoing HCC research Serve on clinical trial review and monitoring committees within the HCC providing critical reviews of proposed and ongoing internal and external clinical trials Provide ongoing education in statistical methods and approaches for members of the HCC

生物统计共享资源 (BSR) 为霍林斯癌症中心提供统计支持和服务中心 (HCC) 调查员。具体服务包括协助资助和试验开发、数据分析、临床试验审查以及监测和教育。对于拨款和协议开发，BSR nelps HCC 研究人员通过协助确定目标和结果、选择适当的研究设计、制定统计分析计划，并执行样本量计算以确定和证明研究中纳入的受试者或患者数量的合理性。 HCC BSR 还积极协助在多种环境下进行数据分析，包括手稿和摘要的准备、初步数据拨款申请以及 HCC 支持的试点项目。 BSR教师参加HCC 方案审查、数据和安全监测委员会对试验进行严格审查，并在为 HCC 的教员、研究员、住院医生和工作人员提供教育机会。 BSR 目前有四名统计员。 BSR 已为所有四项 HCC 研究提供服务本申请中提出的计划以及癌症预防和控制的发展计划。自从 2007 年 2 月任命了新的 BSR 主管后，BSR 的使用量急剧增加。上一年度已提交 37 项资助，27 份手稿和摘要在 BSR 的支持下提交。这些努力证明了当前 BSR 的高利用率 HCC 研究人员，以及 BSR 对 HCC 研究目标的坚定承诺。 BSR 的具体目的是：与 HCC 研究人员合作进行研究开发、实施和出版，提供协助研究设计、统计分析计划、样本量考虑、统计分析、以及拨款和手稿准备根据需要，利用、调整和开发新颖的统计方法来应对挑战正在进行的 HCC 研究中的研究问题在 HCC 内的临床试验审查和监测委员会任职，提供严格审查拟议的和正在进行的内部和外部临床试验为 HCC 成员提供统计方法和方法的持续教育