Gridless Simulation of Flow-MPHV Interaction

流动与 MPHV 相互作用的无网格仿真

• 批准号: 6832970
• 负责人: ADRIN GHARAKHANI
• 金额: $ 10万
• 依托单位: APPLIED SCIENTIFIC RESEARCH
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-08-01 至 2005-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6832970
• 关键词: bioengineering /biomedical engineering; computer program /software; computer simulation; computer system design /evaluation; fluid flow; fluidity; medical implant science; molecular dynamics; prosthetic heart valve

DESCRIPTION (provided by applicant): The objective of this project is to develop a grid-free CFD software for the simulation and analysis of the complex dynamics of the Fluid-Structure Interaction (FSI) associated with Mechanical Prosthetic Heart Valve (MPHV) "systems" as they respond to physiologically realistic 3-D pulsatile flow, which includes laminar and turbulent flow regimes as well as transition between the two regimes. The final product will be the first commercially available grid-free "virtual MPHV test chamber", which can be used by scientists and heart valve designers, for example, to investigate new hypotheses on the hemodynamic aspect of cardiac physiology; to perform parametric studies in order to design new or to improve existing prosthetic valves; or to establish criteria for MPHV implantation (e.g. orientation) under which valve performance will be acceptable. The research aims specifically at (1) coupling an existing MPI-parallel, fast Lagrangian vortex element method with a structural dynamics code, and (2) validating the resultant software using physiologically realistic test cases.

描述（由申请人提供）： 该项目的目标是开发一种无网格 CFD 软件，用于模拟和分析与机械假体心脏瓣膜 (MPHV)“系统”相关的流固耦合 (FSI) 的复杂动力学，因为它们对生理现实做出响应3-D 脉动流，包括层流和湍流流态以及两种流态之间的过渡。最终产品将是第一个商用的无网格“虚拟 MPHV 测试室”，科学家和心脏瓣膜设计者可以使用它来研究心脏生理学血流动力学方面的新假设；进行参数研究以设计新的或改进现有的人工瓣膜；或建立 MPHV 植入标准（例如方向），在该标准下瓣膜性能是可接受的。该研究的具体目标是 (1) 将现有的 MPI 并行、快速拉格朗日涡元方法与结构动力学代码相结合，以及 (2) 使用生理上真实的测试用例验证所得软件。

项目成果

Isolation, quantitation, and characterization of a stable complex formed by Lp[a] binding to triglyceride-rich lipoproteins.

Lp[a] 与富含甘油三酯的脂蛋白结合形成的稳定复合物的分离、定量和表征。

• 发表时间: 2001
• 期刊: Journal of lipid research
• 影响因子: 6.5
• 作者: Gaubatz,JW;Hoogeveen,RC;Hoffman,AS;Ghazzaly,KG;Pownall,HJ;GuevaraJr,J;Koschinsky,ML;Morrisett,JD
• 通讯作者: Morrisett,JD