Gridless Simulation of Flow-MPHV Interaction

流动与 MPHV 相互作用的无网格仿真

• 批准号: 7446201
• 负责人: ADRIN GHARAKHANI
• 金额: $ 37.5万
• 依托单位: APPLIED SCIENTIFIC RESEARCH
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-08-01 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7446201
• 关键词: 3-Dimensional; Cardiac; Complex; Computational Technique; Computer software; Coupling; Heart Valve Prosthesis; Heart Valves; Liquid substance; Mechanics; Methods; Performance; Physiology; Prosthesis; Pulsatile Flow; Research; Scientist; Structure; System; Testing; Time; design; hemodynamics; implantation; improved; simulation; virtual

DESCRIPTION (provided by applicant): The objective of this project is to develop a CFD software for the grid-free simulation and analysis of the complex dynamics of the Fluid-Structure Interaction (FSI) associated with Mechanical Prosthetic Heart Valve (MPHV) "systems" as they respond to physiologically realistic 3-D pulsatile flow. The final product will be the first commercially available grid-free "virtual MPHV test chamber," which can be used by scientists and heart valve designers, for example, to investigate new hypotheses on the unsteady hemodynamic aspect of cardiac physiology; to perform parametric studies in order to design new or to improve existing prosthetic valves; or to establish criteria for MPHV implantation (e.g. orientation) under which valve performance will be acceptable. The specific research aims are to (1) develop accurate methods for fluid force calculations on the valves and implement the coupling between the fluid and the valve; (2) implement computational techniques to further improve adaptivity, user friendliness and CPU turn around times; and (3) validate the resultant software using physiologically realistic test cases.

描述（由申请人提供）：该项目的目的是开发一个CFD软件，用于无网型模拟和分析流体结构相互作用（FSI）（FSI）（FSI）与机械假体心脏阀（MPHV）“系统”相关的“系统”，因为它们可以响应生理上现实的3-D脉冲流。最终产品将是第一个可商购的无网式“虚拟MPHV测试室”，例如，科学家和心脏瓣膜设计师可以使用它来研究有关心脏生理不稳定血液动力学方面的新假设；进行参数研究以设计新的或改善现有的假体阀；或建立MPHV植入标准（例如取向），根据该标准，阀门可以接受。具体的研究目的是（1）开发阀门上的流体力计算的准确方法，并在流体和阀之间实施耦合； （2）实施计算技术，以进一步提高适应性，用户友好性和CPU的扭曲时间； （3）使用生理上现实的测试用例验证所得软件。