Gridless Simulation of Flow-MPHV Interaction

流动与 MPHV 相互作用的无网格仿真

• 批准号: 7446201
• 负责人: ADRIN GHARAKHANI
• 金额: $ 37.5万
• 依托单位: APPLIED SCIENTIFIC RESEARCH
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-08-01 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7446201
• 关键词: 3-Dimensional; Cardiac; Complex; Computational Technique; Computer software; Coupling; Heart Valve Prosthesis; Heart Valves; Liquid substance; Mechanics; Methods; Performance; Physiology; Prosthesis; Pulsatile Flow; Research; Scientist; Structure; System; Testing; Time; design; hemodynamics; implantation; improved; simulation; virtual

DESCRIPTION (provided by applicant): The objective of this project is to develop a CFD software for the grid-free simulation and analysis of the complex dynamics of the Fluid-Structure Interaction (FSI) associated with Mechanical Prosthetic Heart Valve (MPHV) "systems" as they respond to physiologically realistic 3-D pulsatile flow. The final product will be the first commercially available grid-free "virtual MPHV test chamber," which can be used by scientists and heart valve designers, for example, to investigate new hypotheses on the unsteady hemodynamic aspect of cardiac physiology; to perform parametric studies in order to design new or to improve existing prosthetic valves; or to establish criteria for MPHV implantation (e.g. orientation) under which valve performance will be acceptable. The specific research aims are to (1) develop accurate methods for fluid force calculations on the valves and implement the coupling between the fluid and the valve; (2) implement computational techniques to further improve adaptivity, user friendliness and CPU turn around times; and (3) validate the resultant software using physiologically realistic test cases.

描述（由申请人提供）：该项目的目标是开发一款 CFD 软件，用于对与机械假体心脏瓣膜 (MPHV) 系统相关的流固相互作用 (FSI) 的复杂动力学进行无网格仿真和分析“因为它们对生理上真实的 3D 脉动流做出反应。最终产品将是第一个商用的无网格“虚拟 MPHV 测试室”，科学家和心脏瓣膜设计者可以使用它来研究心脏生理学不稳定血流动力学方面的新假设；进行参数研究以设计新的或改进现有的人工瓣膜；或建立 MPHV 植入标准（例如方向），在该标准下瓣膜性能是可接受的。具体研究目标是：（1）建立精确的阀门流体力计算方法，实现流体与阀门的耦合； (2) 实施计算技术以进一步提高适应性、用户友好性和CPU周转时间； (3) 使用生理上真实的测试用例验证生成的软件。