APD to Measure the Resistance of the Respiratory System

APD 测量呼吸系统阻力

基本信息

批准号：
6833027
负责人：
JAFAR VOSSOUGHI
金额：
$ 10万
依托单位：
ENGINEERING AND SCIENTIFIC RESEARCH ASSO
依托单位国家：
美国
项目类别：
财政年份：
2004
资助国家：
美国
起止时间：
2004-09-16 至 2006-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6833027
关键词：
biomedical device power system biomedical equipment development clinical biomedical equipment clinical research computer assisted diagnosis computer program /software computer system design /evaluation cost effectiveness diagnosis design /evaluation emergency care human subject miniature biomedical equipment patient oriented research portable biomedical equipment respirators respiratory airflow disorder respiratory airflow measurement respiratory airway pressure

项目摘要

DESCRIPTION (provided by applicant): Respiratory screening and diagnosis is an important part of medicine and health. Incidences of asthma, chronic obstructive pulmonary disease, and emphysema have grown to epidemic proportions in the last few years. Hospital ventilators are being used more and more for life support for the very young, very old, and all those in between. Traditional pulmonary function tests are not always adequate to provide the respiratory resistance information required by health care professionals. The Airflow Perturbation Device (APD) has been under development for many years, and has undergone significant improvement. The APD is relatively simple in concept: it uses a rotating wheel in the flow path to change flow and mouth pressure by small amounts. From these changes, resistance can be calculated. The APD is simple in operation: it requires only normal breathing for a short time, and can be used by the very young as well as adults. It can show resistance changes as they occur. It can be modified to measure resistance of ventilated patients and can be made as small and portable as a camera. The APD in present form has been used on nearly 1000 people. Normal values of average respiratory resistance have been determined. Resistances in the inhalation and exhalation directions have also been obtained. The APD has been used to find that adhesive nasal strips can reduce nasal resistance by about 10%, and it has been used to demonstrate the transient reduction of resistance following exercise. It should also be able to help titrate bronchodilator doses in hospital patients. In order to bring the APD into commercial production, some further refinements are necessary. After that, clinical data must be obtained, and regulatory approval must be sought. The market for the APD is huge, including all hospitals, clinics, physician's offices, ambulances, and home care facilities in the world. It can also be used in veterinary settings. In Phase I work we plan to further develop the system to be battery-operated, low weight, portable, and less expensive. It will be clinically tested on at least 200 individuals.

描述（由申请人提供）：呼吸系统筛查和诊断是医学和健康的重要组成部分。过去几年，哮喘、慢性阻塞性肺病和肺气肿的发病率已达到流行病的程度。医院呼吸机越来越多地被用于为幼儿、老年人以及所有介于两者之间的人提供生命支持。传统的肺功能测试并不总是足以提供医疗保健专业人员所需的呼吸阻力信息。气流扰动装置（APD）已经开发多年，并且已经有了显着的改进。 APD 的概念相对简单：它使用流路中的旋转轮来少量改变流量和口压。根据这些变化，可以计算出阻力。 APD操作简单：只需要短时间的正常呼吸，幼儿和成人都可以使用。它可以显示电阻发生的变化。它可以经过修改以测量通气患者的阻力，并且可以做得像相机一样小且便于携带。目前的 APD 已在近 1000 人身上使用。平均呼吸阻力的正常值已确定。还获得了吸气和呼气方向的阻力。 APD 已被用于发现粘性鼻带可降低约 10% 的鼻阻力，并已被用于证明运动后阻力的短暂降低。它还应该能够帮助滴定医院患者的支气管扩张剂剂量。为了将 APD 投入商业生产，需要进行一些进一步的改进。之后，必须获得临床数据，并寻求监管部门的批准。 APD 的市场巨大，包括世界上所有的医院、诊所、医生办公室、救护车和家庭护理设施。它也可用于兽医环境。在第一阶段的工作中，我们计划进一步开发电池供电、重量轻、便携且价格便宜的系统。它将在至少 200 人身上进行临床测试。