BIOMECHANICS OF MALE/FEMALE HYPERTENSIVE/ATHEROSCLEROTIC SWINE AORTA

雄性/雌性高血压/动脉粥样硬化猪主动脉的生物力学

• 批准号: 6107007
• 负责人: JAFAR VOSSOUGHI
• 金额: $ 13.19万
• 依托单位: UNIVERSITY OF THE DISTRICT OF COLUMBIA
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-01 至 1999-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6107007
• 关键词: aorta; atherosclerosis; biomechanics; cardiovascular function; computer graphics /printing; computer simulation; gender difference; hypertension; mathematical model; muscle function; statistics /biometry; swine; vascular smooth muscle

In our preliminary and previous studies, we have evaluated limited aspects of mechanical and histomorphological properties of aortic tissues from normotensive and hypertensive dogs and from normal and atherosclerotic/calcified rabbit aortas. In the proposed work, we will extend our previous work to extensively study the in-vivo and in-vitro mechanical properties and histomorphology of porcine thoracic and abdominal aortas. The animal model would be large pigs (50-60 Kg). The pig is an ideal animal model to study the human cardiovascular system in health and disease. We will use four groups of pigs (6 each), the first group will be the control group (normotensive and non-atherosclerotic). The second group will be the hypertensive group where the pigs will be rendered hypertensive using the Goldblatt clamping technique. In the third group, we will produce diet-induced atherosclerosis. The fourth group of animals will have both hypertension and also atherosclerosis. Each group will have both male and female animals (6 each). The significant advantages of our proposed study can be listed as: 1) The pig is the most appropriate animal model in human cardiovascular studies, 2) most studies on animal models are conducted using male animals. We will include in our study, both male and female pigs, 3) since most patients having cardiovascular disease are the elderly and in most elderly both diseases (hypertension and atherosclerosis) are present, our model is producing animals with simultaneous hypertension and atherosclerosis is more appropriate to study human cardiovascular disease, 4) we will produce significant data on mechanical properties of atherosclerotic and hypertensive/atherosclerotic vessels. Such data is urgently needed to initiate finite element models to simulate the angioplasty of human diseased arteries. Our long-term goal is to extend this finite element analysis to an in line clinical system to successfully predict the results of angioplasty in order to reduce or eliminate re-stenosis.

在我们的初步和之前的研究中，我们评估了有限的方面 主动脉组织的机械和组织形态学特性 血压正常和高血压的狗以及正常和 动脉粥样硬化/钙化兔主动脉。 在拟议的工作中，我们将把之前的工作扩展到广泛 研究体内和体外机械性能和组织形态学 猪胸主动脉和腹主动脉。 动物模型会很大 猪（50-60 公斤）。 猪是研究人类的理想动物模型 心血管系统的健康和疾病。 我们将使用四组 猪（每头 6 头），第一组为对照组（血压正常， 非动脉粥样硬化）。 第二组是高血压组 使用戈德布拉特钳夹使猪患上高血压 技术。 在第三组中，我们将生产饮食诱导的 动脉粥样硬化。 第四组动物同时患有高血压 还有动脉粥样硬化。 每组都有男性和女性 动物（各 6 只）。 我们提出的研究的显着优点可列举为： 1） 猪是人类心血管研究中最合适的动物模型， 2）大多数动物模型研究都是使用雄性动物进行的。 我们 我们的研究中将包括雄性和雌性猪，3）因为大多数 患有心血管疾病的患者都是老年人，而且大多数老年人 这两种疾病（高血压和动脉粥样硬化）都存在，我们的模型是 生产同时患有高血压和动脉粥样硬化的动物 更适合研究人类心血管疾病，4）我们将生产 动脉粥样硬化和动脉粥样硬化的机械特性的重要数据 高血压/动脉粥样硬化血管。 迫切需要此类数据 建立有限元模型来模拟人体血管成形术 患病的动脉。 我们的长期目标是扩展这个有限元 对在线临床系统进行分析以成功预测结果 血管成形术以减少或消除再狭窄。