CHILDREN WITH DRUG EXPOSURE: BEHAVIOR AND MRI STUDY

接触药物的儿童：行为和 MRI 研究

• 批准号: 6665424
• 负责人: HAROLYN MILLICENT EDITH BELCHER
• 金额: $ 13.79万
• 依托单位: HUGO W. MOSER RES INST KENNEDY KRIEGER
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-27 至 2005-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6665424
• 关键词: behavior modification; behavioral /social science research tag; bioimaging /biomedical imaging; brain imaging /visualization /scanning; brain mapping; child behavior; child behavior disorders; clinical research; drug abuse; human subject; longitudinal human study; magnetic resonance imaging; middle childhood (6-11); neuroanatomy; neurophysiology; neuropsychology; training

DESCRIPTION (provided by applicant): Magnetic Resonance Imagining (MRI) allows quantitative assessment of specific brain regions that may advance our understanding of brain development and function in children. Development of protocols to promote compliance in unsedated young children during anatomic MRI (aMRI) scans has significant clinical, therapeutic, and research importance. Through the performance ofnon-invasive, unmedicated neuroimaging studies, valuable neuroanatomical and physiological information may be obtained without the risk of adverse consequences to the child. The aims of this proposal are to conduct a preliminary study to: (1) evaluate two behavioral motion control training protocols for early school-aged children, (2) compare two automated methods (Talairach versus revised Talairach) of the brain parcellation to manual parcellation of specific cortical regions in young children, and (3) use aMRI to analyze specific cortical areas in children with intrauterine drug exposure (IUDE) compared to non-drug exposed children. The proposed study of sixty 6 year-old-children (30 with and 30 without IUDE) will use a randomized design to evaluate two behavioral motion control protocols. Following behavioral training the children will receive an MRI for comparison of automated versus manual cortical parcellation techniques on a subset of the MRI studies and volumetric assessment of specific cortical regions on all MRI studies. It is hypothesized that (1) children who receive computer-assisted differential performance feedback and rewards contingent on inhibiting motion during mock scanner rehearsal will demonstrate greater motion control during actual MRI compared to children who receive mock scanner rehearsal with non-contingent rewards, (2) the revised Talairach method of subparcellation will yield improved volumetric measures compared to the Talairach method, and (3) children with IUDE will demonstrate volumetric differences in frontal and parietal regions of the brain compared to non-drug exposed children. An age-, gender- and IQ- matched cohort of sixty children from an on-going longitudinal NIH funded (NR03442-08; PI: Arlene Butz, RN, Sc.D) grant evaluating 254 children with and without IUDE will serve as the research subject source for the proposed study. The funds requested would cover the cost of performing and analyzing the randomized trial to determine which protocol for motion control training is most effective and evaluation and analysis of 60 aMRI from children with and without IUDE. The behavioral protocol outcome data, neuroimaging data, and longitudinal study data will be used to develop an RO1 research application to the National Institute on Drug Abuse to study the potential neuropsychological and neuroanatomical differences in the larger longitudinal study cohort.

描述（由申请人提供）：磁共振成像（MRI）可以对特定的大脑区域进行定量评估，这可能会增进我们对儿童大脑发育和功能的理解。制定协议以促进未镇静幼儿在解剖 MRI (aMRI) 扫描期间的依从性具有重要的临床、治疗和研究重要性。通过进行非侵入性、非药物性神经影像学研究，可以获得有价值的神经解剖学和生理学信息，而不会对儿童产生不良后果的风险。本提案的目的是进行初步研究：(1) 评估针对学龄早期儿童的两种行为运动控制训练方案，(2) 比较两种大脑分区自动化方法（Talairach 与修订版 Talairach）与手动分区(3) 使用 aMRI 分析宫内药物暴露 (IUDE) 儿童与非药物暴露儿童的特定皮质区域。拟议的研究对象是 60 名 6 岁儿童（30 名有宫内节育器，30 名没有宫内节育器），将使用随机设计来评估两种行为运动控制方案。行为训练后，孩子们将接受 MRI 扫描，以比较 MRI 研究子集的自动皮质分割技术与手动皮质分割技术，以及所有 MRI 研究中特定皮质区域的体积评估。假设 (1) 与接受模拟扫描仪排练和非条件奖励的儿童相比，在模拟扫描仪排练期间接受计算机辅助差异表现反馈和根据抑制运动而给予奖励的儿童将在实际 MRI 期间表现出更好的运动控制能力，(2 ) 与 Talairach 方法相比，修订后的 Talairach 子分区方法将产生改进的体积测量，并且 (3) 患有 IUDE 的儿童将表现出大脑额叶和顶叶区域的体积差异与未接触药物的儿童相比。来自 NIH 持续资助的纵向研究（NR03442-08；PI：Arlene Butz，RN，Sc.D）资助的 60 名儿童的年龄、性别和智商匹配队列将作为评估 254 名患有和不患有 IUDE 的儿童的研究对象。拟议研究的研究主题来源。所申请的资金将用于支付执行和分析随机试验的费用，以确定哪种运动控制训练方案最有效，以及对患有和不患有宫内节育器的儿童的 60 个 aMRI 进行评估和分析。行为方案结果数据、神经影像数据和纵向研究数据将用于向国家药物滥用研究所开发 RO1 研究应用程序，以研究更大的纵向研究队列中潜在的神经心理学和神经解剖学差异。