fMRI of CBT and CM for Cocaine Dependence

可卡因依赖的 CBT 和 CM 的功能磁共振成像

• 批准号: 7127192
• 负责人: Marc N Potenza
• 金额: $ 36.3万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-29 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7127192
• 关键词: behavior modification; behavior prediction; behavioral /social science research tag; bioimaging /biomedical imaging; cingulate gyrus; clinical research; cocaine; cognitive behavior therapy; craving; drug abuse therapy; drug addiction; functional magnetic resonance imaging; human subject; human therapy evaluation; neural information processing; neurophysiology; neuropsychology; patient oriented research; prefrontal lobe /cortex; reinforcer; visual stimulus

DESCRIPTION (provided by applicant): We aim to study the neural mechanisms of behavioral treatment of cocaine dependence. Although multiple behavioral treatments including cognitive behavioral therapy (CBT) and contingency management (CM) have been shown to be effective in the treatment of cocaine dependence and other addictive disorders, little is known regarding the brain changes underlying their mechanisms of action. We propose integrating functional magnetic resonance imaging (fMRI) measures into a NIDA-funded behavioral treatment trial of CBT and CM to investigate brain function before and after treatment. We propose using at study onset and following 12 weeks of treatment three imaging paradigms that assess cocaine craving, reward processing and cognitive control, respectively. We propose using similar measures in a non-addicted control grouped imaged twice twelve weeks apart as an important comparison group. We predict that prior to treatment, cocaine dependent subjects will differ from controls on these fMRI and cognitive measures. We also predict that cocaine dependent subjects will show changes in fMRI and cognitive/behavioral functioning following treatment, and that control subjects will not show similar changes when imaged 12 weeks apart. Neural predictors and correlates of effective behavioral treatment for cocaine dependence for CBT and CM will be explored as these would have significant potential for refining therapies, and targeting specific therapies to specific forms of cocaine dependence (e.g., those with specific neural activation patterns). Successful completion of this project would lay the foundation for future studies (e.g., those combining behavioral and pharmacological treatments) in cocaine dependence and other addictive disorders.

描述（由申请人提供）：我们的目标是研究可卡因依赖行为治疗的神经机制。尽管包括认知行为疗法（CBT）和应急管理（CM）在内的多种行为疗法已被证明可有效治疗可卡因依赖和其他成瘾性疾病，但对其作用机制背后的大脑变化知之甚少。我们建议将功能磁共振成像 (fMRI) 测量纳入 NIDA 资助的 CBT 和 CM 行为治疗试验中，以调查治疗前后的大脑功能。我们建议在研究开始时和治疗 12 周后使用三种成像范式，分别评估可卡因渴望、奖励处理和认知控制。我们建议在非成瘾对照组中使用类似的措施，该对照组间隔十二周进行两次成像，作为重要的对照组。我们预测，在治疗之前，可卡因依赖受试者在这些功能磁共振成像和认知测量方面将与对照组有所不同。我们还预测，可卡因依赖受试者在治疗后将表现出功能磁共振成像和认知/行为功能的变化，而对照受试者在相隔 12 周进行成像时不会表现出类似的变化。将探索针对 CBT 和 CM 的可卡因依赖的有效行为治疗的神经预测因子和相关性，因为这些对于改进疗法以及针对特定形式的可卡因依赖（例如具有特定神经激活模式的那些）具有针对性的特定疗法具有巨大潜力。该项目的成功完成将为可卡因依赖和其他成瘾性疾病的未来研究（例如行为和药物治疗相结合的研究）奠定基础。