Pediatric fMRI Technology Development

儿科功能磁共振成像技术开发

• 批准号: 6665426
• 负责人: Victor Andrew Stenger
• 金额: $ 12.16万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-27 至 2005-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6665426
• 关键词: adolescence (12-20); amygdala; basal ganglia; behavioral /social science research tag; bioimaging /biomedical imaging; brain mapping; child (0-11); child behavior; clinical research; decision making; functional magnetic resonance imaging; human subject; neural information processing; neuroanatomy; neuropsychology; nucleus accumbens; technology /technique development

DESCRIPTION (provided by applicant): Disturbances in the neural circuitry underlying reward processing and decision making are likely to be associated with an increased risk common emotional and addictive disorders that have their origins in childhood and adolescence. These disorders include depression and alcohol and nicotine abuse and dependence. It has now become possible to use fMRI to investigate this neural circuitry, together with its developmental trajectory and relationship with critical key physiological events such as puberty. However, these studies are severely hampered by critical methodological limitations, including the presence of magnetic susceptibility effects resulting in signal loss in many key brain regions (ventral striatum, amygdala, orbital frontal cortex), as well as issues related to the cross registration of sub-cortical and orbital frontal brain regions to facilitate the analysis of within and between group comparisons. In the present application, our multidisciplinary group of investigators will tackle these technical limitations and develop and validate solutions designed to improve our ability to investigate this brain circuitry and its development in healthy as well disordered groups of children and adolescents. We will optimize a rapid event-related Reward Contingent Decision (RCD) paradigm for acquisition of data in children and adolescents. We will also develop a whole-brain data acquisition method for rapid event-related pediatric fMRI at 3T that is robust to susceptibility artifacts by combining 3D tailored RF pulse excitations with SENSE acquisitions. Finally, we shall develop a novel volumetric image, deformable registration algorithm especially for deep sub-cortical gray matter structures such as the amygdala and the basal ganglia, including nucleus accumbens. The long term goals of this research are to take maximal advantage of the opportunity provided by event- related fMRI to achieve a better understanding of the development of neurobehavioral systems of reward that influence decision-making and risk appraisal in adolescence, achieve a more mechanistic understanding of the emergence of sensation seeking, risk-taking, and reckless behavior during adolescent development, and to use these methodological advances in fMRI to provide a more powerful cognitive neuroscientific framework for our ongoing developmental and clinical investigations into emotional and substance-use problems emerging during adolescence.

描述（由申请人提供）：奖励处理和决策的神经回路中的干扰可能与风险增加的常见情绪和成瘾性疾病有关，这些疾病起源于童年和青春期。这些疾病包括抑郁，酒精以及尼古丁滥用和依赖性。现在，可以使用fMRI研究这种神经回路，以及其发育轨迹以及与关键关键生理事件（如青春期）的关系。但是，这些研究受到关键方法论上的局限性的严重阻碍，包括存在磁化率效应，导致许多关键的大脑区域（腹侧纹状体，杏仁核，轨道额叶皮层）的信号损失，以及与尺寸和轨道额叶区域的交叉注册相关的问题，以促进组内和组之间的分析。在本应用中，我们的跨学科研究人员将应对这些技术局限性，并开发和验证解决方案，旨在提高我们研究这种脑电路及其在健康的儿童和青少年群体中的发展能力及其发展。我们将优化与事件相关的快速奖励有决策（RCD）范式，以获取儿童和青少年的数据。我们还将开发一种全脑数据采集方法，用于在3T处使用与事件相关的快速小儿fMRI，通过将3D量身定制的RF RF脉冲激发与感官获取相结合，对易感性伪像具有稳健性。最后，我们将开发出一种新型的体积图像，可变形的登记算法，尤其是针对深层皮层灰质结构，例如杏仁核和基底神经节，包括伏隔核。 The long term goals of this research are to take maximal advantage of the opportunity provided by event- related fMRI to achieve a better understanding of the development of neurobehavioral systems of reward that influence decision-making and risk appraisal in adolescence, achieve a more mechanistic understanding of the emergence of sensation seeking, risk-taking, and reckless behavior during adolescent development, and to use these methodological advances in fMRI to provide a more powerful cognitive neuroscientific我们正在进行的发展和临床研究对青春期出现的情绪和物质使用问题的框架。