Impact of Land Cover Change on Hantavirus Ecology

土地覆盖变化对汉坦病毒生态的影响

• 批准号: 6803679
• 负责人: Colleen B Jonsson
• 金额: $ 49.84万
• 依托单位: SOUTHERN RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-03-12 至 2008-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6803679
• 关键词: Hantavirus; Native Americans; Peromyscus; Rodentias; South America; agriculture; animal population study; clinical research; computer system design /evaluation; disease reservoirs; disease vectors; ecology; epidemiology; host organism interaction; human subject; information systems; interdisciplinary collaboration; mathematical model; phlebotomy

DESCRIPTION (provided by applicant): Like most nations in South America, Paraguay is faced with a number of environmental challenges. Both of its major biomes (Chaco, Interior Atlantic Forest/lAF) are currently undergoing rapid anthropogenic land cover change. We hypothesize that the rapid anthropogenic land cover change occurring in Paraguay will have a direct impact on ecosystem viability as well as biodiversity and, therefore, will effect rodent-hantavirus ecology. We propose to test this hypothesis by longitudinal monitoring of anthropogenically disturbed and undisturbed sites in the Chaco and IAF. The data will be used to develop predictive models of the relationship between anthropogenic environmental changes and the dynamics of hantaviruses in rodent populations. Furthermore, the data collection and the model building efforts will concentrate on sigmodontine rodents of the three genera: Oligoryzomus, Akodon and Calomys and the hantaviruses that have been identified from each. Our overarching objective requires a multidisciplinary, binational effort. Therefore, this proposal brings together scientists with strengths in mammalogy (Owen, Texas Tech University, TTU), landscape ecology and climatology (Goodin and Hutchinson, Kansas State University, KSU), mathematical modeling (Allen, TTU), human epidemiology (Almiron, Health Sciences Research Institute, IICS in Spanish), computer science (Ranjan, Pontelli, Tran, New Mexico State University, NMSU), and virology (Jonsson, Southern Research Institute). Our specific objectives are: (1) to longitudinally monitor, measure, and model how the distribution and population of rodents and hantaviruses change over time in each biome within disturbed (anthropogenic activity) and undisturbed study sites in the IAF and the Chaco; (2) to develop models of the temporal and spatial dynamics of rodent-virus ecology; and (3) to design and implement a database management system to integrate these types of data for hantaviruses.

描述（由申请人提供）：与大多数南美洲国家一样，巴拉圭面临着许多环境挑战。其两个主要生物群落（查科、内大西洋森林/lAF）目前正在经历快速的人为土地覆盖变化。我们假设巴拉圭发生的快速人为土地覆盖变化将对生态系统的生存能力和生物多样性产生直接影响，因此将影响啮齿动物汉坦病毒生态。我们建议通过对查科和 IAF 中受人为干扰和未干扰地点的纵向监测来检验这一假设。这些数据将用于开发人为环境变化与啮齿动物种群中汉坦病毒动态之间关系的预测模型。此外，数据收集和模型构建工作将集中于三个属的乙齿象啮齿动物：Oligoryzomus、Akodon 和 Calomys，以及从每个属中鉴定出的汉坦病毒。我们的总体目标需要多学科、两国共同努力。因此，该提案汇集了哺乳动物学（Owen，德克萨斯理工大学，TTU）、景观生态学和气候学（Goodin 和 Hutchinson，堪萨斯州立大学，KSU）、数学建模（Allen，TTU）、人类流行病学（Almiron，健康科学研究所，西班牙语 IICS）、计算机科学（Ranjan、Pontelli、Tran、新墨西哥州立大学、NMSU）和病毒学（Jonsson、南方研究院).我们的具体目标是：(1) 纵向监测、测量和建模 IAF 和查科受干扰（人类活动）和未受干扰研究地点内每个生物群落中啮齿动物和汉坦病毒的分布和种群如何随时间变化； (2) 开发啮齿动物病毒生态学的时空动态模型； (3)设计和实现一个数据库管理系统来集成汉坦病毒的这些类型的数据。