Enhancement of Resilience of the UTHSC RBL Facility, Biosafety and Countermeasure Discovery

增强 UTHSC RBL 设施的弹性、生物安全和对策发现

基本信息

批准号：
10793951
负责人：
Colleen B Jonsson
金额：
$ 229.71万
依托单位：
UNIVERSITY OF TENNESSEE HEALTH SCI CTR
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-08-18 至 2028-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10793951
关键词：
Abbreviations Acceleration Accountability Animal Model Area Basic Science Bioterrorism Certification Client Collaborations Communication Communities Competence Containment Core Facility Dedications Development Diagnostic Educational workshop Emerging Communicable Diseases Ensure Equipment Equipment and supply inventories Facility Controls Fostering General Population Goals Government Health Health Sciences Heart Histology Hospitals Image Individual Infectious Agent Infrastructure International Laboratories Leadership Maintenance Mechanics Medical Medical center Mission Molecular Chaperones Monitor Pediatric Hospitals Persons Pharmaceutical Preparations Pharmacodynamics Preventive Productivity Protocols documentation Publications Research Research Personnel Research Support Resource Sharing Safety Saint Jude Children&apos s Research Hospital Secure Security Services Strategic Planning Strategic vision Structure System Tennessee Training Translational Research Universities Vaccines Viral X-Ray Computed Tomography animal tissue antimicrobial biodefense drug development drug discovery efficacy study end of life experimental study good laboratory practice imaging modality improved infectious disease model laboratory facility lectures medical countermeasure meetings novel therapeutics operation pandemic preparedness pandemic response pathogen prevent professional atmosphere programs promote resilience

项目摘要

Project Abstract The University of Tennessee Health Science Center (UTHSC) Regional Biocontainment Laboratory (RBL) resides within the campus in downtown Memphis in the heart of the medical district. The medical district includes St. Jude Children’s Hospital, Regional One Health Hospital, Memphis VA Medical Center, and Le Bonheur Children’s Hospital. The overarching mission of the UTHSC RBL is to provide leadership and support in the discovery and development of new drugs, vaccines and diagnostics that would protect the general population from emerging and reemerging infectious diseases and bioterrorism. The RBL supports and fosters basic research and translational research that leads to the development of countermeasures for biodefense and emerging infectious agents. In addition to the regional entities above, we support research for academic, government and commercial entities, nationally and internationally. The long-range objectives and goals of the UC7 proposal focus on the creation of three Cores to support RBL management and operations, and enhance and facilitate medical countermeasure research for biodefense, emerging infectious diseases, and pandemic preparedness and response at the RBL. The overall objectives and strategic plan for the operation and use of the RBL and the Facilities Core (Objective 1), BSL-3 Practices Core (Objective 2) and the Biocontainment Research Support Service Core (Objective 3). Objective 1. To provide a Facility Management, Maintenance and Operation Core that will integrate preventive maintenance of mechanical and vivarium infrastructure and scientific / biosafety equipment necessary for BSL-3 and ABSL-3 containment. Objective 2. To provide a BSL- 3 Practices Core that will integrate the management of operations and training for BSL-3 pathogens of which some are select agents, promotes communication and harmonize compliance, security, individual competency, and practices across our RBL Staff and our Users. Objective 3. To facilitate and advance research within the Biocontainment Research Support Service(s) Core under the umbrella of the “Antiviral & Antimicrobial Countermeasures Discovery & Development Core’ (herein abbreviated as A2CD2C). The A2CD2C is unique within the RBL network in its focus on providing LCMS/MS studies for infected, treated animal tissues in BSL-3 and providing drug pharmacodynamics. The strategic mission for Operation and Use of the RBL and the three Cores is to provide a seamless and integrated management and operational structure that efficiently serves its clients and users with the appropriate facility controls, biosafety and select agent compliance. Our strategic vision in this regard is to provide leadership for the RBL network and scientific community and share best practices and discoveries through lectures and publications.

项目摘要田纳西大学健康科学中心 (UTHSC) 区域生物防护实验室 (RBL) 位于孟菲斯市中心医疗区的校园内。医疗区包括。圣裘德儿童医院、地区一级健康医院、孟菲斯退伍军人医疗中心和 Le Bonheur UTHSC RBL 的首要任务是在儿童医院提供领导和支持。发现和开发能够保护普通大众的新药、疫苗和诊断方法 RBL 支持和促进基本的预防措施。研究和转化研究导致生物防御对策的发展除了上述区域实体外，我们还支持学术研究、国内和国际政府和商业实体的长期目标和目标。 UC7提案重点关注创建三个核心来支持RBL管理和运营，并增强促进生物防御、新发传染病和大流行病的医疗对策研究 RBL 的准备和响应运营和使用的总体目标和战略计划。 RBL 和设施核心（目标 1）、BSL-3 实践核心（目标 2）和生物防护研究支持服务核心（目标 3）。提供设施管理、维护。运营核心将整合机械和动物园基础设施的预防性维护 BSL-3 和 ABSL-3 遏制所需的科学/生物安全设备目标 2. 提供 BSL-3。 3 个实践核心，将整合 BSL-3 病原体的运营管理和培训，其中有些是精选代理，促进沟通并协调合规性、安全性、个人能力，目标 3. 促进和推进研究。生物遏制研究支持服务核心在“抗病毒和抗菌对策发现与开发核心”（本文缩写为 A2CD2C）。 A2CD2C 在 RBL 网络中是独一无二的，它专注于为受感染、接受治疗的动物提供 LCMS/MS 研究 BSL-3 中的组织并提供药物药效学的操作和使用的战略任务。 RBL 和三个核心旨在提供一个无缝、集成的管理和运营结构，通过适当的设施控制、生物安全和选择代理，有效地为客户和用户提供服务我们在这方面的战略愿景是为 RBL 网络和科学提供领导力。社区并通过讲座和出版物分享最佳实践和发现。