PCB Congener/Metabolite Patterns in Akwesasne Mohawks

Akwesasne Mohawks 中的 PCB 同系物/代谢物模式

• 批准号: 6879884
• 负责人: ANTHONY P DECAPRIO
• 金额: $ 22.56万
• 依托单位: STATE UNIVERSITY OF NEW YORK AT ALBANY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-01 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6879884
• 关键词: Native Americans; bioaccumulation; biomedical registry /referral center; blood tests; clinical research; environmental exposure; environmental toxicology; epidemiology; halobiphenyl /halotriphenyl compound; hazardous substances; human subject; information systems

DESCRIPTION (provided by applicant): In partnership with the Mohawk Nation at Akwesasne, the University at Albany has conducted extensive investigation of polychlorinated biphenyl (PCB) contamination at Akwesasne and has collected a large amount of exposure, health, and clinical data for Mohawk children and adults. The long-term objective of research in this laboratory is to identify individual determinants of polychlorinated biphenyl (PCB) body burden, including those related to consumption of contaminated biota, in the Akwesasne Mohawks and in other exposed populations. Body burden, which is characterized by the absolute and relative levels of individual polychlorinated biphenyl (PCB) congeners present in tissue, is an important predictor of potential health impairment from polychlorinated biphenyls (PCBs). Multiple exposure-related and toxicokinetics-mediated factors can influence polychlorinated biphenyl (PCB) body burden. This renewal application will expand current work on characterizing polychlorinated biphenyl (PCB) exposure in the Akwesasne Mohawk population by application of multivariate exploratory data analysis and other statistical techniques, with the goal of identifying source-, route-, and toxicokinetics-specific exposure indicators. The presence of five major contributing serum polychlorinated biphenyl (PCB) profiles previously identified in Mohawk adults will be correlated with relevant demographic, exposure, and environmental variables. The study will be expanded to include comparative analyses of polychlorinated biphenyl (PCB) profiles determined in a cohort of Mohawk children and adolescents. To provide data to assess current body burden, time-dependent changes in congener profiles, and elimination kinetics of individual congeners, new blood specimens will be analyzed from 100 adults. Finally, a complementary database of major serum hydroxylated polychlorinated biphenyl (PCB) metabolites in adult Mohawks will be established for comparative statistical analysis. These proposed studies are expected to facilitate ongoing exposure and health effects studies of polychlorinated biphenyls (PCBs) at Akwesasne and are important for understanding the potential health risks from these compounds in general.

描述（由申请人提供）：与Akwesasne的Mohawk Nation合作，奥尔巴尼大学在Akwesasne对多氯联苯的二苯基（PCB）污染进行了广泛的调查，并收集了大量的Mohawk儿童和成人的暴露，健康，健康和临床数据。 该实验室研究的长期目的是确定多氯联苯（PCB）体重的个体决定因素，包括与污染生物群，Akwesasne Mohawks和其他裸露人群中的消费量有关的人体负担。 身体负担的特征是组织中存在的单个多氯联苯（PCB）同源物的绝对水平和相对水平，是多氯联苯（PCB）潜在健康障碍的重要预测指标。 多重暴露有关的和有毒动力学介导的因子会影响多氯联苯（PCB）的身体负担。 该更新应用将通过应用多变量探索性数据分析和其他统计技术来扩展目前表征Akwesasne Mohawk人群中多氯联苯（PCB）暴露的目前工作，目的是识别源，路由和毒理学特异性暴露指标。 先前在莫霍克族成年人中鉴定出的五个主要促进血清多氯联苯（PCB）谱的存在将与相关的人口统计学，暴露和环境变量相关。 该研究将扩展到包括在莫霍克族儿童和青少年队列中确定的多氯联苯（PCB）剖面的比较分析。 为了评估当前身体负担，同类物概况的时间依赖性变化以及单个同类物的消除动力学，将对100名成年人分析新的血液标本。 最后，将建立成人莫霍克族人中主要血清羟化多氯联苯（PCB）代谢产物的补充数据库，以进行比较统计分析。 这些提出的研究有望促进Akwesasne多氯联苯（PCB）的持续暴露和健康影响研究，对于理解一般化合物的潜在健康风险非常重要。