Asymmetric Epoxidation of Olefins by Chiral Dioxiranes

手性二环氧乙烷对烯烃的不对称环氧化

• 批准号: 6755182
• 负责人: YIAN SHI
• 金额: $ 30.84万
• 依托单位: COLORADO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-08-01 至 2007-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6755182
• 关键词: alkenes; chemical reaction; chemical stability; chemical synthesis; epoxides; ethylene oxide; ketones; stereochemistry

DESCRIPTION (provided by applicant): The overall goal of the proposed research is to explore the mechanistic features and synthetic potential of chiral dioxiranes. The specific aims of the proposed research are: (1) to understand the mechanism and transition states involved in asymmetric epoxidation of olefins by chiral dioxiranes; (2) to further design and search for new ketone catalysts with high stability, reactivity, and enantioselectivity; (3) to explore and expand the scope of dioxirane-mediated asymmetric epoxidation; (4) to apply the newly developed asymmetric epoxidation to the synthesis of useful chiral building blocks and biologically active compounds.

描述（由申请人提供）：本研究的总体目标是探索手性二氧杂环己烷的机理特征和合成潜力。本研究的具体目的是：（1）了解手性二氧杂环己烷对烯烃的不对称环氧化反应的机理和过渡态； （2）进一步设计和寻找具有高稳定性、反应活性和对映选择性的新型酮催化剂； (3)探索并拓展双环氧乙烷介导的不对称环氧化的范围； (4)将新开发的不对称环氧化应用于有用的手性结构单元和生物活性化合物的合成。