ASYMMETRIC EPOXIDATION OF OLEFINS BY CHIRAL DIOXIRANES

手性二氧杂环己烷对烯烃的不对称环氧化

• 批准号: 2883959
• 负责人: YIAN SHI
• 金额: $ 24.93万
• 依托单位: COLORADO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-08-01 至 2003-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2883959
• 关键词: alkenes; chemical synthesis; epoxides; ethylene oxide; stereoisomer

DESCRIPTION: (Applicant's Abstract) The overall goal of the proposed research is to explore the mechanistic features and synthetic potential of chiral dioxiranes. The specific aims of the proposed research are: (1) to understand the mechanism and transition states involved in asymmetric epoxidation of olefins by chiral dioxiranes; (2) to further design and search for new ketone catalysts with high stability, reactivity, and enantioselectivity; (3) to explore and expand the scope of dioxirane-mediated asymmetric epoxidation; (4) to apply the newly developed asymmetric epoxidation to the synthesis of useful building blocks and biologically active compounds.

描述：（申请人的摘要）拟议研究的总体目标 旨在探索手性分子的机理特征和合成潜力 二恶烷。本研究的具体目标是：（1）了解 不对称环氧化反应的机理和过渡态 由手性二环氧乙烷制备烯烃； (2)进一步设计和寻找新的酮 具有高稳定性、反应活性和对映选择性的催化剂； (3) 至 探索并扩大双环氧乙烷介导的不对称环氧化的范围； (4) 将新开发的不对称环氧化应用于有用的合成 结构单元和生物活性化合物。