Nano Silver-Hydroxyapatite Coatings - biocompatibility with oral cells to improve abutment integrity for periodontal health.

纳米银羟基磷灰石涂层 - 与口腔细胞的生物相容性，可改善基台完整性，促进牙周健康。

• 批准号: 2432313
• 金额: --
• 依托单位: Plymouth University
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2432313
• 关键词: Nano; Silver; Hydroxyapatite; Coatings; biocompatibility

This project is an exciting opportunity to develop novel silver-hydroxyapatite nanocoatings to reduce failure of dental implants. The interdisciplinary project combines nanotechnology with leading biomedical science expertise, in a real-world clinical setting to investigate the biocompatibility of antibacterial nanocoatings with oral cells to improve abutment integrity for periodontal health. Despite the high success rates of dental implants, 5-10% of them are still reported to fail and must be removed. One of the most common causes of implant failure is peri-implantitis, which is caused by bacterial biofilm formation on the implant surfaces. Modification of the surface nanotopography has been identified as one of the strategies to control bacterial adherence to implants and improve clinical outcomes. Silver nanoparticles are known for their antibacterial properties, whereas hydroxyapatite is a chemical similar to the mineral component of natural bone and teeth. Our team has demonstrated that silver-hydroxyapatite hybrid nanocoatings applied to the surface of medical implants are antibacterial but also biocompatible with human osteoblasts, suggesting good fusion of the implants to the jaw bone is achieved. However, shrinkage of the gingiva at the abutment margins, with subsequent infection and micro-leakage in the sub-gingival crevice can lead to implant failure, as well as other oral health problems.

该项目是一个令人兴奋的机会，可以开发新型的银羟基磷灰石纳米涂料以减少牙科植入物的衰竭。跨学科项目将纳米技术与领先的生物医学专业知识相结合，在现实世界中的临床环境中，研究抗菌纳米涂层具有口腔细胞的生物相容性，以改善牙周健康的基础完整性。尽管牙科植入物的成功率很高，但仍有5-10％的植入术据报道失败，必须删除。植入物衰竭的最常见原因之一是植入体炎，这是由植入物表面的细菌生物膜形成引起的。表面纳米形状的修饰已被确定为控制细菌遵守植入物并改善临床结局的策略之一。银纳米颗粒以其抗菌特性而闻名，而羟基磷灰石是一种类似于天然骨和牙齿的矿物质成分的化学物质。我们的团队已经证明，应用于医疗植入物表面的银羟基磷灰石杂交纳米涂料是抗菌性的，但也与人成骨细胞具有生物相容性，这表明植入物的良好融合到颌骨上。然而，牙龈在基端边缘的收缩，随后的感染和微裂解在亚生物缝隙中会导致植入物衰竭以及其他口腔健康问题。