Brain Imaging of Tobacco Craving Using fMRI

使用功能磁共振成像对烟草渴望进行脑成像

• 批准号: 6515852
• 负责人: CHRIS-ELLYN JOHANSON
• 金额: $ 35.03万
• 依托单位: WAYNE STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-05-01 至 2004-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6515852
• 关键词: bioimaging /biomedical imaging; clinical research; craving; drug /alcohol abstinence; drug addiction; emotions; functional magnetic resonance imaging; human subject; neuropharmacology; nicotine; smoking; tobacco abuse

DESCRIPTION: (provided by applicant) Over this last decade, research on the significance of craving in understanding the neurobiological basis of addiction and for developing new therapies that specifically target craving has increased exponentially with special funding initiatives promulgated by both NIDA and NIAAA. Several investigators have embarked upon neuroimaging studies to identify the brain regions mediating the subjective and behavioral manifestations of craving. The purpose of this application is to utilize well-established imagery techniques for the elicitation of craving for cigarettes in conjunction with fMRI to identify the specific brain regions whose pattern of activation is associated with craving. One feature of the proposed research is the use of imagery procedures in which smoking-urge material is presented in a context that also produces positive, negative or neutral emotional mood states that are matched in terms of vividness. Those patterns of brain activation associated with craving, and independent of the emotional context, are of special interest. Prior research indicating the importance of limbic system activation during periods of drug craving will guide our research. However, the present design allows the determination of whether the emotional tone provoked by craving material is important in determining the pattern of brain activation. The results of this research will provide techniques for studying potential behavioral and pharmacological treatment interventions using both self-report of craving and fMRI patterns of brain activation as end points. Further, the development of reliable and valid self-report and fMRI techniques for studying the neural correlates of craving will permit future research examining how variables that modulate self-reported measures of craving change the pattern of brain activation. Those areas of brain activation that are most strongly associated with variations in self-reports of craving are most likely to be of functional significance and therefore potentially important end points for pharmacological interventions. Finally, because nicotine dependence is a prototypic addiction, this research should provide a model for similar research with other drug dependencies.

描述：（由申请人提供）在过去的十年中，关于 渴望对于理解成瘾的神经生物学基础的重要性 以及开发专门针对渴望增加的新疗法 NIDA 和 NIDA 颁布的特别资助举措呈指数级增长 NIAAA。一些研究人员已经开始进行神经影像学研究 识别调节主观和行为的大脑区域 贪爱的表现。该应用程序的目的是利用 用于激发渴望的成熟的意象技术 香烟与功能磁共振成像相结合来识别特定的大脑区域 其激活模式与渴望有关。其特点之一是 拟议的研究是使用图像程序，其中吸烟冲动 材料呈现的背景也会产生积极、消极或 中性的情绪情绪状态与生动性相匹配。那些 大脑激活模式与渴望相关，并且独立于 情感背景，特别令人感兴趣。先前的研究表明 在药物渴望期间激活边缘系统的重要性 指导我们的研究。然而，本设计允许确定 对物质的渴望所引发的情绪基调是否重要 确定大脑激活的模式。这项研究的结果将 提供研究潜在行为和药理学的技术 使用自我报告的渴望和功能磁共振成像模式进行治疗干预 大脑激活作为终点。此外，开发可靠有效的 用于研究渴望的神经相关性的自我报告和功能磁共振成像技术 将允许未来的研究检查变量如何调节自我报告 渴望的测量改变了大脑的激活模式。那些领域 与以下变化最密切相关的大脑激活 自我报告的渴望最有可能具有功能意义，并且 因此，药物干预的潜在重要终点。 最后，由于尼古丁依赖是一种原型成瘾，本研究 应该为其他药物依赖性的类似研究提供一个模型。