Career Development and Mentoring in Clinical/Translational Alcohol Research

临床/转化酒精研究的职业发展和指导

• 批准号: 8509462
• 负责人: RAYMOND F ANTON
• 金额: $ 21.62万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-06-05 至 2018-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8509462
• 关键词: Alcohol dependence; Alcoholic Liver Diseases; Alcohols; American; Area; Association of American Medical Colleges; Award; Basic Science; Biological; Biological Markers; Biology; Biomedical Research; Brain; Brain imaging; Clinical; Clinical Research; Clinical Trials; Collaborations; Consultations; Core Facility; Development; Diagnostic tests; Diffusion; Disease; Educational Status; Ensure; Epigenetic Process; Faculty; Fibrosis; Functional Magnetic Resonance Imaging; Funding; Future; Genetic; Genomics; Glycoproteins; Grant; Human; Image; Individual Differences; Instruction; Internal Medicine; International; Knowledge; Leadership; Learning; Liver; Magnetic Resonance Spectroscopy; Measurement; Medical Students; Medicine; Mentors; Mentorship; National Institute on Alcohol Abuse and Alcoholism; Neurosciences; Pathology; Patients; Peer Review; Pharmacogenomics; Pharmacological Treatment; Physicians; Population; Positioning Attribute; Postdoctoral Fellow; Productivity; Proteomics; Psychiatry; Psychology; Publications; Reading; Research; Research Infrastructure; Research Personnel; Research Training; Resources; Science; Scientist; Secure; Seminal; Senior Scientist; Senior Scientist Award; Serum; Societies; Structure; Techniques; Technology; Time; Training; Training Programs; Transferrin; Translational Research; United States National Institutes of Health; Variant; Work; addiction; alcohol abuse therapy; alcohol effect; alcohol research; alcohol response; base; bioimaging; career; career development; cost; craving; disease diagnosis; drinking; effective therapy; experience; medical specialties; meetings; neuroimaging; next generation; public health relevance; responsible research conduct; skills; statistics; success; tool; treatment response

DESCRIPTION (provided by applicant): The Senior Scientist Research and Mentorship Award is targeted for "outstanding senior scientists who have demonstrated a sustained level of high productivity conducting biomedical research" in order to protect their time to continue research while mentoring the "next generation" of investigators. With more than 25 years of experience in clinical alcohol research (over 20 clinical trials, seminal work in craving (OCDS), biomarkers of drinking (CDT), neuroimaging, and more recently in genetic and pharmacogenomics), over 15 years of continued R01 funding, 16 years of being a Scientific Director of an Alcohol Research Center, with 245 peer reviewed publications, and international recognition, the candidate meets and exceeds the requirements as an outstanding senior scientist. He has been elected to high leadership positions of leading academic/research societies, a previous leader of the COMBINE Study, and is sought out as a mentor for his expertise in bridging the gap between basic and clinical research. He has accomplished this while maintaining an active training program in alcohol research, including 20 years as Director or Co-Director of an NIAAA-sponsored T32 Research Training Grant. He has personally mentored 34 professionals (23 MDs and 11 PhDs), 20 of those in the past 4 years. Many have secured career development and independent alcohol research funding and remain tied to the alcohol field. His understanding of both the mechanisms of, and applications to, the treatment of alcohol disorders is atypical and rare. This award is important to the candidate for two major reasons. First, it will provide him with protected time to keep his alcohol research career on the cutting edge by enabling him to continue formal and informal training in genetics (e.g. epigenetics), proteomics (e.g. glycoproteomics), and new/advanced neuroimaging skills (fMRI connectivity analysis, diffusion kurtosis, and H1-magnetic resonance spectroscopy), apply these essential areas of science to his own alcohol research (as outlined), and communicate new discoveries to the alcohol treatment field in general. Second, this award will provide the candidate with protected time from additional clinical and administrative duties to apply his vast experience and newly acquired skills to his mentoring activities and the development of younger clinical- scientists. With the NIH and the American Association of Medical Colleges highlighting the large, unmet need in the U.S. for clinical and translational researchers (especially in the area of genomics) and with millions of Americans suffering from alcohol disorders, who are underserved and who cost the US economy over $200 billion each year, there is a need to push clinical research forward, a need to ensure our senior scientists are on the cutting edge in their own research, and a need to train future scientists to carry on this research to find effective treatments. This K05 Senior Scientist Career and Mentoring Award will allow this to happen.

描述（由申请人提供）：高级科学家研究和指导奖旨在奖励“在生物医学研究中表现出持续高生产力水平的杰出高级科学家”，以保护他们继续研究的时间，同时指导“下一代”的调查员。拥有超过 25 年的临床酒精研究经验（超过 20 项临床试验、酒瘾研究 (OCDS)、饮酒生物标志物 (CDT)、神经影像学以及最近在遗传和药物基因组学方面的开创性工作），超过 15 年的持续 R01 资助担任酒精研究中心科学主任 16 年，发表过 245 篇同行评审出版物，并获得国际认可，该候选人满足并超过了作为杰出高级科学家的要求。他曾被选为领先学术/研究协会的高级领导职务，曾担任 COMBINE 研究的领导者，并因其在弥合基础研究和临床研究之间差距方面的专业知识而被视为导师。他在实现这一目标的同时，还积极开展酒精研究方面的培训计划，其中包括担任 NIAAA 资助的 T32 研究培训基金的主任或联合主任 20 年。他亲自指导了 34 名专业人士（23 名医学博士和 11 名博士），其中 20 名是在过去 4 年中培养的。许多人已经获得了职业发展和独立酒精研究资金，并仍然与酒精领域保持联系。他对酒精障碍治疗机制和应用的理解是非典型且罕见的。该奖项对候选人来说很重要，主要有两个原因。首先，这将为他提供受保护的时间，使他能够继续在遗传学（例如表观遗传学）、蛋白质组学（例如糖蛋白质组学）和新的/先进的神经影像技能（功能磁共振成像连接）方面进行正式和非正式的培训，从而使他的酒精研究事业保持在最前沿。分析、扩散峰度和 H1 磁共振波谱），将这些重要的科学领域应用到他自己的酒精研究中（如概述），并将新发现传达给整个酒精治疗领域。其次，该奖项将为候选人提供受保护的时间，使其免于额外的临床和行政职责，将其丰富的经验和新获得的技能应用于指导活动和年轻临床科学家的发展。美国国立卫生研究院和美国医学院协会强调，美国对临床和转化研究人员（特别是在基因组学领域）存在巨大且未得到满足的需求，并且数百万美国人患有酒精障碍，他们得不到充分的服务，并付出了高昂的代价每年经济超过2000亿美元，需要推动临床研究向前发展，需要确保我们的资深科学家在自己的研究中处于前沿，并且需要培训未来的科学家进行这项研究以找到有效的治疗方法。 K05 高级科学家职业和指导奖将使这一切成为可能。