Comparing Effects of 3 Sources of Garlic on Serum Lipids

比较 3 种大蒜来源对血清脂质的影响

• 批准号: 6687700
• 负责人: CHRISTOPHER D GARDNER
• 金额: $ 50.05万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-07-15 至 2005-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6687700
• 关键词: allyl compound; alternative medicine; angiosperms; antioxidants; biological products; blood lipid; blood pressure; cholesterol; clinical research; clinical trials; diet therapy; dietary supplements; food processing /preparation; human middle age (35-64); human subject; human therapy evaluation; hypercholesterolemia; hyperlipidemia; nutrition related tag; patient oriented research; plant extracts; triglycerides

DESCRIPTION (provided by applicant): BACKGROUND: Garlic supplements are the most consumed herbal products in the US. The most common health claims made for these products is that of cholesterol lowering. This claim has not been supported by 7 recent clinical trials and 2 recent meta-analyses. However, the data suggest that it is not garlic, per se, that has been ineffective, but the particular garlic preparations being used. To date, the type of garlic preparation used in these clinical trials has predominantly been dried garlic powders. A few clinical trials have reported beneficial lipid effects using an aged garlic extract, and only a small number of weak and inconclusive uncontrolled trials have used fresh garlic. A rigorous trial directly comparing different types of garlic preparations for their effects on serum lipids is needed. OBJECTIVE: To decisively determine whether fresh garlic can positively affect serum lipids in moderately hyperlipidemic adults and whether the same effects can be found for two main types of garlic supplements: a dried powdered garlic designed to yield the same bioactive agents in vivo as fresh garlic (GARLICIN) and an aged garlic extract preparation (KYOLIC). DESIGN: 220 adults with moderately elevated LDL-cholesterol (LDL-C) will be randomized to one of 4 groups for 6 months: fresh garlic, Garlicin tablets, Kyolic tablets, or Control. Both the fresh garlic and control groups will receive placebo tablets. The fresh garlic will be provided to participants with "study sandwiches," and all other groups will receive the same sandwiches, but without the garlic. The primary outcome will be 6-month changes in LDL-C levels. Secondary outcomes will include HDL-cholesterol, triacylglycerols, platelet function, antioxidant status and blood pressure. IMPLICATIONS: This investigation will address 1) the magnitude of the effect on serum lipids, 2) the debate over the most effective type of garlic preparation, and 3) previous criticisms as to the transience of the effect. The comprehensive approach taken in this study will provide important evidence for both the public and for health professionals as to whether fresh garlic or garlic supplements have beneficial effects on serum lipids.

描述（由申请人提供）：背景：大蒜补充剂是 美国消费最多的草药产品。最常见的健康声明 这些产品的作用是降低胆固醇。此主张尚未得到 得到最近 7 项临床试验和 2 项荟萃分析的支持。然而， 数据表明，并不是大蒜本身无效，而是大蒜本身无效。 使用特殊的大蒜制剂。迄今为止，大蒜的种类 这些临床试验中使用的制剂主要是干大蒜 粉末。一些临床试验报告了使用 陈蒜提取物，只有少数弱且无定论 非对照试验使用了新鲜大蒜。严格的试验直接比较 不同类型大蒜制剂对血脂的影响 需要。目的：决定性地确定新鲜大蒜是否可以积极地 影响中度高脂血症成人的血脂以及是否相同 两种主要类型的大蒜补充剂具有功效：干粉大蒜 大蒜旨在在体内产生与新鲜大蒜相同的生物活性剂 （GARLICIN）和陈蒜提取物制剂（KYOLIC）。设计：220 名成人 低密度脂蛋白胆固醇 (LDL-C) 中度升高将被随机分配至 4 项中的一项 6 个月组：新鲜大蒜、大蒜素片、Kyolic 片或 控制。新鲜大蒜组和对照组都将服用安慰剂片剂。 新鲜大蒜将与“学习三明治”一起提供给参与者， 所有其他小组将收到相同的三明治，但没有大蒜。这 主要结果是 6 个月内 LDL-C 水平的变化。次要结果 包括高密度脂蛋白胆固醇、三酰甘油、血小板功能、抗氧化剂 状态和血压。影响：本次调查将解决 1) 对血脂影响的大小，2) 关于最有效的争论 大蒜制备的类型，以及 3) 之前对大蒜的短暂性的批评 的效果。本研究采用的综合方法将提供 对于公众和卫生专业人员来说，重要证据 新鲜大蒜或大蒜补充剂是否对血清有益 脂质。