Noninvasive Devices for fMRI Studies in Drug Abuse -II

用于药物滥用 fMRI 研究的无创设备 -II

• 批准号: 6584745
• 负责人: Craig F Ferris
• 金额: $ 25万
• 依托单位: INSIGHT NEUROIMAGING SYSTEMS, LLC
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-06-01 至 2005-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6584745
• 关键词: Macaca mulatta; bioimaging /biomedical imaging; biomedical equipment development; blood pressure; brain electrical activity; brain mapping; cocaine; corticosterone; drug abuse; drug screening /evaluation; functional magnetic resonance imaging; heart rate; neuroimaging; noninvasive diagnosis; restraint

DESCRIPTION (provided by applicant): Insight Neuroimaging System's, LLC (INSL) mission is to develop and manufacture non-invasive tools for studying brain development, chemistry and function. INSL specializes in radiofrequency coils for ultra-high field magnetic resonance imaging for use in animal studies. MR signal is optimized by a dual coil design for RF transmission and reception. The dual coil RF electronics are built into custom, designed restrainers for non-invasive imaging with minimal stress and discomfort to the animal. INSL products have been successfully used to image fully conscious rodents and small monkeys. With STTR Phase I funding INSL developed, constructed and bench tested dual-coil animal restrainer for the large rhesus monkey. Phase I I funding will be used for field-testing, product optimization, and incorporation of an operant control panel and monitor for cognitive studies in the rhesus system. During field studies monkeys will been tested in a simulated imaging procedure to habituate them to the stress of the restrainer. Thereafter, subjects will be imaged for functional changes under control and stimulated conditions. Based upon the results of the habituation and the imaging studies, modifications will be made in the restrainer and RF electronics to optirnize the rhesus system. The INSL rhesus system can be adapted to any of the thousands of horizontal, human scanners as well as the many hundreds of dedicated horizontal animal systerns. This technology will greatly enhance preclinical research in developmental neurobiology, neurological diseases, mental illness and drug addiction.

描述（由申请人提供）：Insight神经影像系统的LLC（INSL）任务是开发和制造用于研究大脑发育，化学和功能的非侵入性工具。 INSL专门从事用于用于动物研究的超高场磁共振成像的射频线圈。 MR信号通过双线圈设计进行优化，用于RF传播和接收。双线圈RF电子设备内置在定制的，设计的约束器中，用于非侵入性成像，对动物的压力和不适感最小。 INSL产品已成功地用于图像完全有意识的啮齿动物和小猴子。随着STTR I期资金，INSL开发，构建和替补师测试了大型恒河猴的双层动物约束。第一阶段I资金将用于现场测试，产品优化以及操作控制面板的合并，并监视恒河部系统中的认知研究。在现场研究期间，将在模拟成像程序中测试猴子，以使其习惯于约束者的压力。此后，将对受试者进行对照和刺激条件下的功能变化成像。根据习惯和成像研究的结果，将在约束器和RF电子设备中进行修改，以选择恒河体系。 INSL恒河类系统可以适应成千上万的水平，人类扫描仪以及数百种专用的水平动物系统。这项技术将大大增强发育神经生物学，神经系统疾病，精神疾病和药物成瘾方面的临床前研究。