RCMI CLINICAL RESEARCH INFRASTRUCTURE INITIATIVE

RCMI 临床研究基础设施计划

• 批准号: 6780428
• 负责人: T SAMUEL SHOMAKER
• 金额: $ 170.65万
• 依托单位: UNIVERSITY OF HAWAII AT MANOA
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-09-30 至 2005-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6780428
• 关键词: Hawaiian; clinical research; health science research support

The success of the RCMI-Clinical Research Center (CRC) at the University of Hawaii (UH) has been challenged by the lack of a university hospital. Thus, the clinical faculty is based at several community hospitals in the Honolulu area with the UH-RCMI-CRC located at one, Kapiolani Medical Center, a specialty women's and children's facility. The major focus of this clinical research center is to foster the development of clinical research that focuses on medical conditions disproportionately affecting Hawaiian minorities. The remarkable success of the UH-RCMI-CRC over the last four years is highlighted by recruitment of a diverse group of investigators from the major community hospitals, as well as investigators from the PACIFIC Biomedical Research Center (PBRC) and the Cancer Research Center of Hawaii (CRCH). Since its inception in September 1995, 99 investigators representing 10 institutions have conducted 86 studies at the UH-RCMI- CRC. During this four-year period, UH-RCMI-CRC supported investigators have published 58 book chapters/reviews, 234 abstracts/presentations, 195 manuscripts, and have been award4ed 23 million dollars in federal grants. In addition, 7 career development applications have been completed. Other proposals have been submitted in response NIH RFAs. Continued support is requested for an additional 5-year term in order to further develop and expand develop and expand the UH-RCMI-CRC, with the specific goal of achieving GCRC status. In order to continue the recruitment of junior investigators from the UH School of Medicine, PBRC and CRCH, the emphasis on protocol development will continue to be a priority. The UH-RCMI-CRC will also continue to assist promising investigators in applying for career development awards. As a major activity, the research infrastructure and clinical facility will be expanded to include a satellite center at another major hospital within the St. Francis Healthcare System. Other goals will be provide nutritional support services, expand the capabilities of the core laboratory to include molecular biology and lipid analysis studies, and establish an affiliation with the University of Vermont-GCRC. In support of major areas of clinical research relevant to the peoples of Hawaii, the UH-RCMI-CRC will foster four areas of clinical research excellence. These include: HIV and Emerging Pathogens, Neonatal/Perinatal Research, Epidemiologic- based Cancer Research, and Native Hawaiian Health. The research efforts of the UH-RCMI-CRC will be seamlessly integrated with the activities of the newly approved Centers of Clinical Research Excellence (CCRE). Finally, our research efforts will be aided by the new Dean of the School of Medicine, Dr. Edwin Cadman from Yale University, who has formally agreed to designate the UH-RCMI-CRC as the central clinical research infrastructure for the School of Medicine.

夏威夷大学（UH）的RCMI-Clinical研究中心（CRC）的成功受到了大学医院缺乏的挑战。因此，临床教师位于檀香山地区的几家社区医院，UH-RCMI-CRC位于特殊的妇女和儿童设施的Kapiolani医疗中心。该临床研究中心的主要重点是促进临床研究的发展，该研究重点是影响夏威夷少数民族的医疗状况不成比例。在过去的四年中，UH-RCMI-CRC在过去的四年中取得了巨大的成功，这是通过招募主要社区医院的一系列研究人员以及来自太平洋生物医学研究中心（PBRC）和夏威夷癌症研究中心（CRCH）的研究人员的招募。自1995年9月成立以来，有99名代表10家机构的调查人员在UH-RCMI-CRC进行了86项研究。 在这四年期间，UH-RCMI-CRC支持的调查人员发表了58本书章节/评论，234篇摘要/演示文稿，195个手稿，并获得了2300万美元的联邦赠款。此外，已经完成了7种职业发展申请。其他提案已提交为NIH RFA。持续的支持将需要额外的5年任期，以进一步发展和扩展UH-RCMI-CRC，并具有达到GCRC身份的具体目标。为了继续从UH医学院，PBRC和CRCH招募初级调查人员，重点将继续是优先事项。 UH-RCMI-CRC还将继续协助有前途的调查人员申请职业发展奖。作为一项重大活动，研究基础设施和临床设施将扩大到在圣弗朗西斯医疗保健系统内另一家主要医院的卫星中心。其他目标将是提供营养支持服务，扩大核心实验室的能力，包括分子生物学和脂质分析研究，并与佛蒙特大学GCRC大学建立隶属关系。为了支持与夏威夷人民有关的临床研究的主要领域，UH-RCMI-CRC将促进卓越临床研究的四个领域。其中包括：艾滋病毒和新兴病原体，新生儿/围产期研究，基于流行病学的癌症研究和夏威夷本地健康。 UH-RCMI-CRC的研究工作将与新认可的临床研究卓越中心（CCRE）的活动无缝集成。最后，我们的研究工作将由耶鲁大学的新医学院院长Edwin Cadman博士提供帮助，他正式同意将UH-RCMI-CRC指定为医学院的中心临床研究基础设施。