Core--Genomics

核心--基因组学

• 批准号: 6747100
• 负责人: MITCHELL L SOGIN
• 金额: $ 10.24万
• 依托单位: WOODS HOLE OCEANOGRAPHIC INSTITUTION
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-01 至 2008-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6747100
• 关键词: algae; aquatic organism; bioinformatics; biomedical facility; biotechnology; computer program /software; data collection methodology /evaluation; data management; functional /structural genomics; marine biology; marine toxins; microorganism population study; saltwater environment; seafood poisoning; statistics /biometry; water microbiology

The Genomics Core Facility will provide access to higher-level bioinformatics capabilities for multiple sequence alignment, and phylogenetic inference or population biology analyses. The faculty and bioinformatics staff of the Bay Paul Center for Comparative Molecular Biology and Evolution has considerable expertise in pure statistics, genome assembly, astrophysical modeling, gene expression, phylogenetics, information management, data acquisition pipelines, and data basing. The combination of this expertise with our advanced computational resources will meet anticipated needs for each of the projects supported by The Woods Hole Center for Oceans and Human Health. Dr. Sogin in consultation with Dr. Andrew McArthur, will advise PIs of individual projects on the use of appropriate computer algorithms. The general approach will be to use CLUSTALX {Jeanmougin, 1998 #27} for the alignment of large data sets. Manual corrections (interactive changes in positioning of gaps) may be used to improve the alignments. The phylogenetic analyses will normally only consider regions where there is confidence in homology of the compared sites.

基因组学核心设施将为多个序列比对以及系统发育推断或种群生物学分析提供高级生物信息学能力的访问。 Bay Paul Paul比较分子生物学和进化中心的教师和生物信息学人员在纯统计，基因组组装，天体物理建模，基因表达，系统发育，信息管理，数据采集管道和数据基础方面具有相当大的专业知识。这种专业知识与我们的先进计算资源的结合将满足伍兹孔海洋和人类健康中心支持的每个项目的预期需求。 Sogin博士与Andrew McArthur博士协商，将向PIS提供有关使用适当计算机算法的个人项目的建议。一般方法将是使用Clustalx {Jeanmougin，1998＃27}进行大型数据集的对齐。手动校正（差距定位的互动变化）可用于改善对齐方式。系统发育分析通常仅考虑对比较位点同源性信心的区域。