ALZHEIMERS DISEASE CORE CENTER

阿尔茨海默病核心中心

• 批准号: 6952584
• 负责人: STEVEN H FERRIS
• 金额: $ 0.2万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-08-20 至 2005-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6952584
• 关键词: Alzheimer' s disease; biomedical facility

The Alzheimers Disease Center (ADC) at New York University School of Medicine is structured as an Alzheimers Disease Core Center (ADCC). It provides core resources and pilot study support to a comprehensive multi-disciplinary research program on Alzheimers Disease (AD). Investigators at the NYS Institute for Basic Research (IBR), the Bellevue Hospital Center (BHC), the Nathan Kline Institute (NKI) and other New York City area facilities are also participating. The ADCC encompasses physical, patient and laboratory resources, relevant research projects and pilot studies and an established group of investigators committed to studying AD. The general goal of the Center is to integrate, expand and facilitate innovative basic and clinical research to extend knowledge about the pathophysiology, early diagnosis and treatments of AD. Patients with AD and related disorders, subjects with mild cognitive impairment and normal elderly subjects are studied longitudinally through postmortem. AD research served by the ADCC include molecular and cellular biology; neuropathologic-clinical correlation; in vivo neuroimaging; clinical symptomatology and longitudinal course; cognition and psychopharmacology; and AD caregiver studies. The ADCC is supervised by a Director and seven Associate leaders who serve on an Executive Committee, an Institutional Steering Committee and an External Scientific Advisory Committee. Cores support consist of Administrative, Clinical (including CSF and Serum/DNA Banks, and a Satellite Diagnostic and Treatment Center [SDTC] focusing on minority recruitment at BHC), Neuroimaging, Neuropathology (including a morphometry component at IBR, and a proposed new satellite at Sun Health Research Institute [SunCity, Az]), Data Management, Caregiver and Education and Information Transfer. Each year, three pilot studies are directly supported by the ADCC. In addition, extensive current research receiving primary support from other sources is facilitated by ADCC core facilities through utilization of core resources. During the current funding period, the core resources have been maintained and the base of AD research at NYU has been expanded, in part through recruitment of established investigators. The new Caregiver core has been added to the Center, and there are increased collaborations with other ADCs.

纽约大学医学院的阿尔茨海默病中心 (ADC) 是一个阿尔茨海默病核心中心 (ADCC)。它为阿尔茨海默病 (AD) 的综合性多学科研究项目提供核心资源和试点研究支持。纽约州基础研究所 (IBR)、贝尔维尤医院中心 (BHC)、内森·克莱恩研究所 (NKI) 和纽约市其他地区设施的研究人员也参与其中。 ADCC 包括物理、患者和实验室资源、相关研究项目和试点研究以及致力于研究 AD 的既定研究人员小组。该中心的总体目标是整合、扩展和促进创新的基础和临床研究，以扩展有关 AD 病理生理学、早期诊断和治疗的知识。通过尸检对患有 AD 和相关疾病的患者、患有轻度认知障碍的受试者和正常老年受试者进行纵向研究。 ADCC 提供的 AD 研究包括分子和细胞生物学；神经病理学-临床相关性；体内神经影像学；临床症状和纵向病程；认知和精神药理学；和 AD 护理人员研究。 ADCC 由一名主任和七名副领导监督，他们在执行委员会、机构指导委员会和外部科学咨询委员会中任职。核心支持包括行政、临床（包括脑脊液和血清/DNA 库，以及专注于 BHC 少数族裔招募的卫星诊断和治疗中心 [SDTC]）、神经影像学、神经病理学（包括 IBR 的形态测量部分，以及拟议的新卫星）在 Sun Health 研究所 [SunCity, Az]），数据管理、护理人员以及教育和信息传输。每年，ADCC 都会直接支持三项试点研究。此外，ADCC 核心设施通过利用核心资源，促进了目前从其他来源获得主要支持的广泛研究。在当前资助期间，纽约大学的核心资源得以保留，AD 研究基础得到了扩大，部分是通过招募现有的研究人员来实现的。该中心已添加新的护理人员核心，并且与其他 ADC 的合作也有所增加。