Core--Clinical Facility

核心--临床设施

• 批准号: 6801289
• 负责人: Ian Frank
• 金额: $ 30.69万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2009-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6801289
• 关键词: AIDS; AIDS therapy; antiAIDS agent; biomedical facility; drug adverse effect; health behavior; health science research support; hepatitis; hepatitis virus; human immunodeficiency virus 1; human subject; information systems; patient /disease registry; patient oriented research; pediatric AIDS; secondary infection; therapy compliance; tissue resource /registry

The University of Pennsylvania Health System (UPHS) provides care to over 2,500 HIV-infected individuals at the Hospital of the University of Pennsylvania, Presbyterian Medical Center, the Philadelphia Veterans Administration Medical Center, Pennsylvania Hospital, and Children's Hospital of Philadelphia. The Clinical Core of the Penn Center for AIDS Research will maintain and expand a longitudinal database that currently includes demographic, behavioral, and clinical information on over 1,600 HIV-infected men, women, adolescents, and children receiving care in the UPHS. The Clinical Core Database can be used to identify potential subjects for study or, when linked with three other campus databases with in-depth clinical information, can be used as a tool for independent clinical investigation. We will expand this Database to include information on 3,000 HIV-infected individuals. In addition, the Clinical Core has created a Specimen Repository, linked to the Database, which contains several thousand banked plasma, serum, and peripheral blood mononuclear cells (PBMCs) collected semiannually. We will continue to collect serum and plasma samples at regular intervals in the future. Fresh PBMCs will be collected by investigator request, and a PBMC sample from each participant will be obtained for preparation of DNA suitable for host genetic analyses. These resources will be used to promote interdisciplinary and translational research on the Penn campus. The Database will be expanded to include new data elements in three areas, metabolic complications of antiretroviral therapy, hepatitis co-infection, and adherence and at-risk behaviors in order to support on-going and planned research of young and new HIV investigators. The Clinical Core will coordinate the collection of a wider range of patient material, including cells collected by apheresis, genital secretions, and adipose tissue. Penn and regional investigators with interests in HIV pathogenesis, antiretroviral therapy and its complications, opportunistic infections, neurological and psychiatric complications, adherence, HIV risk behaviors and transmission, and quality of life will be brought together to expand the focus of current research and establish collaborations across fields of interest.

宾夕法尼亚大学卫生系统（UPHS）在宾夕法尼亚大学，长老会医疗中心，费城退伍军人管理局医疗中心，宾夕法尼亚州医院和费城儿童医院的医院和费城医院。宾夕法尼亚州艾滋病研究中心的临床核心将维护和扩展一个纵向数据库，该数据库目前包括人口统计学，行为和临床信息，涉及1,600多名HIV感染的男性，女性，女性，青少年和儿童在UPHS接受护理。临床核心数据库可用于识别潜在的研究对象，或者与其他三个具有深入临床信息的校园数据库相关联时，可以用作独立临床研究的工具。我们将扩展此数据库，包括有关3,000名HIV感染者的信息。此外，临床核心创建了一个与数据库相关的标本存储库，该存储库包含数千个银行的血浆，血清和外周血单核细胞（PBMC），每半年收集。将来，我们将继续定期收集血清和血浆样品。将通过研究人员的要求收集新的PBMC，并将获得每个参与者的PBMC样本，以制备适合宿主遗传分析的DNA。这些资源将用于促进宾夕法尼亚州校园的跨学科和翻译研究。该数据库将扩展到包括三个领域的新数据元素，抗逆转录病毒疗法的代谢并发症，肝炎共同感染以及依从性和处于危险的行为以支持持续的 并计划对年轻和新艾滋病毒研究者的研究。临床核心将协调 收集了更广泛的患者材料，包括通过分离术，生殖器分泌和脂肪组织收集的细胞。宾夕法尼亚州和区域研究人员对HIV发病机理，抗逆转录病毒疗法及其并发症，机会性感染，神经和精神病并发症，依从性，HIV风险行为以及传播以及生活质量将聚集在一起，以扩大目前研究的重点并建立跨感兴趣的领域的协作。