XL-I Analytical Ultracentrifuge and Fluorescence Optics

XL-I 分析超速离心机和荧光光学器件

• 批准号: 6580649
• 负责人: ASHUTOSH TRIPATHY
• 金额: $ 38.45万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-04-01 至 2005-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6580649
• 关键词: analytical ultracentrifugation; biomedical equipment purchase

DESCRIPTION (provided by applicant): The UNC Macromolecular Interactions Facility, also called "Mac-In-Fac" (web address: macinfac.bio.unc.edu), is a core facility of the University of North Carolina at Chapel Hill. The facility has been operating since 1996. The facility has a Biacore X, a Biacore 2000, a Beckman Optima XL-A analytical ultracentrifuge with scanning UV/VIS optics, a fluorescence spectrophotometer, differential scanning and isothermal titration calorimeters, circular dichroism spectropolarimeters, and static and dynamic light scattering instruments. There are no similar facilities on the UNC Chapel Hill Campus, or nearby institutions. Its current users come from 11 departments on the UNC Chapel Hill campus (Biochemistry & Biophysics, Biology, Cell Biology, Chemistry, Microbiology & Immunology, Pathology, Pediatrics, Pharmacology, Pharmacy, Physics, and Physiology), other academic and research institutions from North Carolina and several Research Triangle Park biotechnology companies. Many of our users have experienced problems while carrying out their projects using the absorbance optics available with the Optima XL-A analytical ultracentrifuge. These and other projects need to be carried out with the interference optics available with the Optima XL-I. Additionally, some other users have a need for an analytical ultracentrifuge with a fluorescence optics-based detection system (please see attached specific research plans). No such instrumentation is available in this geographical area (Chapel Hili-Raleigh-Durham- RTP). Therefore, the Mac-ln-Fac requests funds for: (1) purchasing an interference and absorbance optics based analytical ultracentrifuge (Beckman Optima XL-I), and (2) purchasing and installing a fluorescence optical detection system in our existing Optima XL-A (this accessory will be manufatured and installed by The Center to Advance Molecular Interaction Sciences (CAMIS), University of New Hampshire).

描述（由申请人提供）：北卡罗来纳大学大分子相互作用设施，也称为“Mac-In-Fac”（网址：macinfac.bio.unc.edu），是北卡罗来纳大学教堂山分校的核心设施。该设施自 1996 年开始运营。该设施拥有 Biacore X、Biacore 2000、带扫描 UV/VIS 光学器件的 Beckman Optima XL-A 分析超速离心机、荧光分光光度计、差示扫描和等温滴定量热计、圆二色分光偏振计和静态和动态光散射仪器。北卡罗来纳大学教堂山校区或附近的机构没有类似的设施。其当前用户来自北卡罗来纳大学教堂山校区的 11 个系（生物化学与生物物理学、生物学、细胞生物学、化学、微生物学与免疫学、病理学、儿科、药理学、药剂学、物理学和生理学）以及北卡罗来纳州的其他学术和研究机构卡罗莱纳州和几家三角研究园生物技术公司。我们的许多用户在使用 Optima XL-A 分析超速离心机提供的吸收光学器件执行项目时遇到了问题。这些项目和其他项目需要使用 Optima XL-I 提供的干涉光学器件来执行。此外，其他一些用户需要带有基于荧光光学的检测系统的分析超速离心机（请参阅随附的具体研究计划）。该地理区域（Chapel Hili-Raleigh-Durham-RTP）没有此类仪器。因此，Mac-ln-Fac 请求资金用于：(1) 购买基于干涉和吸收光学的分析超速离心机 (Beckman Optima XL-I)，以及 (2) 在我们现有的 Optima XL 中购买并安装荧光光学检测系统A（该配件将由新罕布什尔大学高级分子相互作用科学中心 (CAMIS) 制造和安装）。