EXONUCLEASE IN THERAPEUTIC RESISTANCE TO ANTITUMOR DRUGS

核酸外切酶在抗肿瘤药物治疗耐药中的作用

• 批准号: 6489107
• 负责人: FRED W PERRINO
• 金额: $ 23.02万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-01-01 至 2004-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6489107
• 关键词: 6 thiopurine; DNA directed DNA polymerase; DNA repair; DNA replication; acute myelogenous leukemia; antineoplastics; chemosensitizing agent; clinical trials; combination cancer therapy; cytosine arabinoside; cytotoxicity; drug interactions; drug metabolism; drug resistance; drug screening /evaluation; enzyme activity; exonuclease; human therapy evaluation; molecular cloning; neoplasm /cancer chemotherapy; neoplastic cell; pharmacokinetics; recombinant proteins; tissue /cell culture

项目成果

Exonucleases and the incorporation of aranucleotides into DNA.

核酸外切酶和将芳香核苷酸掺入 DNA。

• 发表时间: 1999
• 影响因子: 2.6
• 作者: Perrino, F W;Mazur, D J;Ward, H;Harvey, S
• 通讯作者: Harvey, S

Identification and expression of the TREX1 and TREX2 cDNA sequences encoding mammalian 3'-->5' exonucleases.

编码哺乳动物 3-->5 核酸外切酶的 TREX1 和 TREX2 cDNA 序列的鉴定和表达。

• 发表时间: 1999-07-09
• 作者: Mazur, D J;Perrino, F W
• 通讯作者: Perrino, F W

Two functional domains of the epsilon subunit of DNA polymerase III.

DNA 聚合酶 III ε 亚基的两个功能域。

• 发表时间: 1999-11-30
• 影响因子: 2.9
• 作者: Perrino, F W;Harvey, S;McNeill, S M
• 通讯作者: McNeill, S M

Structure and expression of the TREX1 and TREX2 3' --> 5' exonuclease genes.

TREX1 和 TREX2 3 --> 5 核酸外切酶基因的结构和表达。

• 发表时间: 2001-05-04
• 作者: Mazur, D J;Perrino, F W
• 通讯作者: Perrino, F W

Elucidation of the epsilon-theta subunit interface of Escherichia coli DNA polymerase III by NMR spectroscopy.

通过 NMR 光谱法阐明大肠杆菌 DNA 聚合酶 III 的 epsilon-theta 亚基界面。

• 发表时间: 2003-04-08
• 作者: DeRose, Eugene F;Darden, Thomas;Harvey, Scott;Gabel, Scott;Perrino, Fred W;Schaaper, Roel M;London, Robert E
• 通讯作者: London, Robert E