Asymmetric Catalysis by Transition Metals

过渡金属的不对称催化

• 批准号: 6752505
• 负责人: GREGORY C FU
• 金额: $ 29.78万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-06-01 至 2007-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6752505
• 关键词: catalyst; chemical reaction; chemical synthesis; heavy metals; heterocyclic compounds; ligands; molecular shape; stereochemistry; stereoisomer

DESCRIPTION (provided by applicant): Due to the "handedness" of the molecules of life (peptides, DNA/RNA, carbohydrates, etc.), enantiomeric compounds often display quite different biological activity. As a result, there is a need for the development of efficient methods for enantioselective organic synthesis. Transition metals catalyze a tremendous array of transformations, many of which cannot readily be accomplished by other types of catalysts. This research program focuses on the development of chiral ligands for transition metal-catalyzed processes. The investigation is comprised of two parts:  the synthesis of new families of ligands based on planar-chiral heterocycles.  the application of these new ligands to the development of highly enantioselective transition metal-catalyzed reactions.

描述（由申请人提供）：由于生命分子（肽，DNA/RNA，碳水化合物等）的“惯用性”，对映体化合物通常显示出完全不同的生物学活性。结果，需要开发有效的有机合成方法的有效方法。过渡金属催化了一系列巨大的转化，其中许多转化无法通过其他类型的催化剂来完成。该研究计划着重于用于过渡金属催化过程的手性配体的发展。调查由两个部分组成： 基于平面性杂环的新配体的新家族的合成。 这些新配体在高度对映选择性金属催化反应的发展中的应用。