Functional Disability as a Measurement of Injury Burden in Children

功能性残疾作为儿童伤害负担的衡量标准

• 批准号: 8348554
• 负责人: Mark Robert Zonfrillo
• 金额: $ 12.56万
• 依托单位: CHILDREN'S HOSP OF PHILADELPHIA
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-01 至 2017-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8348554
• 关键词: 18 year old; 3-Dimensional; Acute; Biomechanics; Caring; Characteristics; Child; Childhood; Childhood Injury; Computer Simulation; Computer software; Databases; Engineering; Environment; Goals; Head; Injury; Lead; Measurement; Modeling; Multiple Trauma; Nature; Patients; Pattern; Performance; Rehabilitation Centers; Rehabilitation therapy; Research; Safety; Seat Belts; Secondary Prevention; Shoulder; Side; Simulate; System; Testing; Traumatic Brain Injury; Vehicle crash; abstracting; disability; functional disability; improved; injury burden; kinematics; mortality; prevent; response; restraint; spinal cord and brain injury; tertiary prevention

DESCRIPTION (provided by applicant): Project Summary/Abstract Motor vehicle crashes continue to be the leading cause of mortality and acquired disability in children. Traumatic brain and spinal cord injuries are typically considered the most disabling of these injuries. However, little is known about the specific patterns of injuries that lead to various degrees of functional disability in children and the biomechanical mechanisms for these crash-related disabling injuries. The broad long-term objective of this line of research is to advance the understanding of the nature and causes of functional disability after pediatric injury in sufficient detail to inorm secondary prevention (improved engineering and injury countermeasures) strategies as well as tertiary prevention (improved acute and rehabilitative care) strategies. As a first step in achieving this goal, the current proposal will focus on motor vehicle crashes as a prototypic mechanism of disabling injury in children. The aims of the project are: 1) To identify the injuries for children 7-18 years old that are associated with moderate to severe functional disability upon discharge from rehabilitation centers, 2) To identify the crash characteristics, direction of impac, occupant contact points, and adequacy of restraint system performance that contribute to the moderately to severely disabling pattern of injuries, and to 3) To create a 3-dimensional dynamic computational model in order to quantify the crash biomechanics, simulate the occupant kinematics, and identify a countermeasure that could mitigate the biomechanical mechanism of injury. PUBLIC HEALTH RELEVANCE: Project Narrative Injuries from motor vehicle crashes are the leading cause of disability in children, but the mechanisms of disabling injuries are poorly understood. By determining biomechanical mechanisms of disabling injuries in children, improved strategies for secondary prevention (improved engineering and injury countermeasures) and tertiary prevention (improved acute and rehabilitative care) of these injuries can be developed.

描述（由申请人提供）： 项目摘要/摘要 机动车辆碰撞事故仍然是儿童死亡和后天残疾的主要原因。创伤性脑部和脊髓损伤通常被认为是这些损伤中最严重的。然而，人们对导致儿童不同程度功能残疾的具体伤害模式以及这些与碰撞相关的致残性伤害的生物力学机制知之甚少。这一研究领域的广泛长期目标是深入了解儿科损伤后功能障碍的性质和原因，以足够详细的方式制定二级预防（改进工程和损伤对策）策略以及三级预防（改进急性损伤）策略。和康复护理）策略。作为实现这一目标的第一步，当前提案将重点关注机动车辆碰撞事故，将其作为儿童致残伤害的原型机制。该项目的目标是： 1) 确定伤害 对于从康复中心出院时患有中度至重度功能障碍的 7-18 岁儿童，2) 确定导致中度至重度功能障碍的碰撞特征、冲击方向、乘员接触点以及约束系统性能的充分性3) 创建 3 维动态计算模型，以量化碰撞生物力学，模拟乘员运动学，并确定可以缓解的对策损伤的生物力学机制。 公共健康相关性：项目叙述 机动车碰撞造成的伤害是儿童残疾的主要原因，但人们对致残伤害的机制知之甚少。通过确定儿童致残性损伤的生物力学机制，可以制定这些损伤的二级预防（改进工程和损伤对策）和三级预防（改进急性和康复护理）的改进策略。