Axis I & Axis II Psychiatric Disorders in Norwegian Twin

轴一

• 批准号: 6778607
• 负责人: KENNETH SEEDMAN KENDLER
• 金额: $ 31.49万
• 依托单位: VIRGINIA COMMONWEALTH UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-05-18 至 2008-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6778607
• 关键词: Scandinavian; alcoholism /alcohol abuse; antisocial personality; anxiety disorders; behavioral /social science research tag; behavioral genetics; borderline personality disorder; clinical research; disease /disorder etiology; epidemiology; family genetics; gene environment interaction; genetic susceptibility; human data; interview; major depression; mental disorder diagnosis; patient /disease registry; personality disorders; pregnancy disorder; twin /multiplet; young adult human (21-34)

DESCRIPTION (provided by applicant): Personality (or axis II) disorders are common, disabling and highly co-morbid with important axis I psychiatric disorders such as major depression and anxiety disorders as well as alcohol abuse/dependence. Personality disorders (PDs) aggregate in families, and existing twin studies suggest this familial aggregation is due partly to genetic factors. However these were based on modest-sized clinical samples or self-report questionnaires and have not been confirmed by an interview-based epidemiologic twin study of PDs. The goal of this application is to conduct detailed analysis of a population-based study of young adult twins in Norway assessed using personal interviews for the lifetime history of both major axis I psychiatric and substance use disorders and all axis II disorders. Data collection -- supported from Norwegian sources --is now 94% complete, and will be finished by 9/30/03 resulting in 1,400 complete twin pairs. We will conduct an extensive series of analyses on this rich data set using both standard and recently developed statistical tools. Aims include: i) examine and correct for attrition effects in the registry; ii) apply both factor and IRT models to generate empirical PD scales; iii) conducting univariate twin analyses to clarify the etiologic role of genetic, shared-environmental and individual specific environment factors for personality disorder traits (PDTs); iv) performing multivariate twin analyses to understand the sources of covariation between both individual PDTs and PD clusters; v) examining a series of theory-driven bivariate twin analyses to determine the degree to which selected pairs of axis I disorders and PDTs reflect the similar or distinct genetic and environmental risk factors such as Major Depression (MD) and Depressive and Borderline PD, Social phobia and Avoidant PD, and Alcohol Abuse/Dependence and Antisocial PD; vi) examine etiologic links between PDs and prospectively collected data on pregnancy and birth complications and vii) attempt to replicate key findings emerging from an on-going study of axis I Disorders in the Virginia Twin Registry. This study has the capacity to address several key and largely unanswered empirical questions about PDs, the answers to which will be critical for proposed revisions in DSM-V.

描述（由申请人提供）：人格（或Axis II）疾病很常见，残疾并与重要的轴心I精神疾病（例如严重抑郁症和焦虑症以及酒精滥用/依赖性）合并。 家族中的人格障碍（PDS）骨料，现有的双胞胎研究表明，这种家族聚集部分归因于遗传因素。但是，这些基于适度的临床样本或自我报告问卷，尚未通过PDS的基于访谈的流行病学双胞胎研究证实。 该应用的目的是对挪威的年轻双胞胎的一项基于人群的研究进行详细分析，并使用个人访谈对主要轴心I精神病学和药物使用障碍以及所有Axis II II疾病进行评估。数据收集 - 从挪威来源支持 - 现在已完成94％，并将在9/30/03完成，导致1,400个完整的双胞胎。 我们将使用标准和最近开发的统计工具对此丰富的数据集进行大量分析。目的包括：i）检查注册表中的流失效应并纠正； ii）应用因子和IRT模型来生成经验PD量表； iii）进行单变量双胞胎分析，以阐明人格障碍特征（PDTS）的遗传，环境和个人特定环境因素的病因作用； iv）进行多元双胞胎分析以了解单个PDT和PD簇之间的协方差源； v）检查一系列由理论驱动的双变量双胞胎分析，以确定选定的轴I疾病对和PDT的程度反映了相似或独特的遗传和环境风险因素，例如重度抑郁症（MD）以及抑郁和边界PD，社会恐惧症和回避性PD，以及酗酒/依赖和反社会PD； vi）检查PDS与预期收集的有关妊娠和出生并发症的数据之间的病因联系以及VII）试图复制弗吉尼亚双子登记中轴心I疾病的持续研究中出现的关键发现。这项研究有能力解决有关PD的几个关键且在很大程度上未解决的经验问题，对于DSM-V中的拟议修订至关重要的答案至关重要。