Hormones During Weight Loss in Breast Cancer Survivors

乳腺癌幸存者减肥过程中的激素

• 批准号: 6744310
• 负责人: CHERYL L ROCK
• 金额: $ 7.6万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-05-01 至 2005-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6744310
• 关键词: behavior therapy; bioenergetics; body composition; body physical activity; breast neoplasms; chromatography; clinical research; clinical trials; estrogens; health behavior; hormone binding protein; hormone regulation /control mechanism; human subject; insulinlike growth factor; long term survivor; obesity; patient oriented research; radioimmunoassay; statistics /biometry; weight control; weight loss; women' s health

DESCRIPTION (provided by applicant) Overweight or obesity is an established negative prognostic factor in both pre-menopausal and postmenopausal breast cancer, and several mechanisms have been proposed to explain this observation. One possible mechanism relates to the effect of excess adipose tissue on circulating gonadal hormones, because adipose tissue is an important extragonadal source of estrogens from precursor adrenal androgens. Obesity is associated with increased circulating concentrations of estrone and estradiol in postmenopausal women, and it also is associated with decreased levels of sex-hormone binding globulin (SHBG), which increases the bioavailable estrogen fraction Another possible mechanism relates to insulin and insulin-like growth factor (IGF)-I, and the interactions of these factors with adiposity and weight Circulating insulin concentration is highly correlated with degree of adiposity in breast cancer survivors In an ongoing NCI-funded randomized controlled study, we are testing the effect of a multi-component weight reduction program on change in body weight and body composition in overweight and obese breast cancer survivors (n=85), and blood samples are collected from the study participants at baseline, 16 weeks (after the intensive treatment phase), and one year. The intervention incorporates cognitive-behavioral therapy, increased physical activity to promote maintenance of (or increased) lean body mass, diet modification to facilitate an energy imbalance, and strategies to improve body image and self-acceptance. The aims of the proposed small grant project are (1) To conduct laboratory assays of SHBG and serum estrogens, and to examine the effect of the intervention on these hormonal factors, in breast cancer survivors participating in a weight reduction program (compared to women in a wait-list control group), using stored blood samples collected at enrollment and following participation, and (2) To conduct laboratory assays of serum insulin, total IGF-I, free IGF-I, and a key binding protein (IGFBP-3) and to examine the effect of the intervention on these hormonal factors in breast cancer survivors participating in the program (compared to women in a wait-list control group), using stored blood samples collected at enrollment and following participation The measurement of hormonal factors and data analyzed in this project will provide vital information about the responsiveness of these hormonal factors to weight loss and change in body composition in overweight and obese breast cancer survivors Also, the results from this study will provide valuable insight about possible mechanisms by which overweight or obesity influences prognosis in women who have been diagnosed with breast cancer.

描述（由申请人提供） 超重或肥胖是绝经前和绝经后乳腺癌的一个既定的负面预后因素，并且已经提出了几种机制来解释这一观察结果。 一种可能的机制与过量脂肪组织对循环性腺激素的影响有关，因为脂肪组织是来自前体肾上腺雄激素的重要性腺外雌激素来源。肥胖与绝经后女性体内雌酮和雌二醇循环浓度升高有关，还与性激素结合球蛋白 (SHBG) 水平降低有关，而性激素结合球蛋白 (SHBG) 会增加生物可利用的雌激素分数。另一种可能的机制与胰岛素和胰岛素样生长有关因子 (IGF)-I，以及这些因素与肥胖和体重的相互作用 循环胰岛素浓度与乳腺癌幸存者的肥胖程度高度相关NCI 资助的随机对照研究，我们正在测试多成分减肥计划对超重和肥胖乳腺癌幸存者 (n=85) 体重和身体成分变化的影响，并从研究参与者身上采集血液样本基线、16 周（强化治疗阶段后）和一年。 该干预措施包括认知行为疗法、增加体力活动以促进维持（或增加）瘦体重、调整饮食以促进能量失衡以及改善身体形象和自我接纳的策略。 拟议的小额赠款项目的目的是 (1) 对参与减肥计划的乳腺癌幸存者进行 SHBG 和血清雌​​激素的实验室测定，并检查干预措施对这些激素因素的影响（与等待名单对照组），使用登记时和参与后收集的储存血样，以及 (2) 对血清胰岛素、总 IGF-I、游离 IGF-I 和关键结合蛋白 (IGFBP-3) 进行实验室测定）并使用入组时和参与后收集的储存血液样本来检查干预措施对参与该计划的乳腺癌幸存者（与等待名单对照组中的女性相比）的这些激素因素的影响。 激素因素和数据的测量本项目中分析的结果将提供有关这些激素因素对超重和肥胖乳腺癌幸存者体重减轻和身体成分变化的反应的重要信息。此外，本研究的结果还将提供有关超重或肥胖影响的可能机制的宝贵见解。被诊断患有乳腺癌的女性的预后。