CORE--PRIMATE

核心——灵长类

• 批准号: 6501126
• 负责人: KENNETH CAREY
• 金额: $ 12.63万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-01 至 2002-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6501126
• 关键词: Macaca mulatta; animal care; animal colony; biomedical facility; low density lipoprotein receptor; transfection /expression vector

The Gene Therapy Primate Core will be located in the Department of Physiology and Medicine at the Southwest Foundation for Biomedical Research in San Antonio, Texas. This core will be responsible for supplying normal and LDL-R defective rhesus monkeys, administering experimental treatments, maintaining subjects that are shedding virus under appropriate containment (biosafety level 2), sampling animals regularly to determine the duration of viral shedding and drawing blood to measure gene expression and lipoprotein kinetics, necropsing animals to gather materials to measure final endpoints, assessing vascular lesions in control and treated animals, and preparing and shipping samples to Baylor College of Medicine in Houston.

基因治疗灵长类动物核心将位于该部门 西南生物医学基金会生理学和医学 德克萨斯州圣安东尼奥市的研究。该核心将负责 供应正常和 LDL-R 缺陷的恒河猴， 实验性治疗，维持正在散发病毒的受试者 在适当的遏制下（生物安全级别 2），对动物进行取样 定期确定病毒脱落和抽血的持续时间 测量基因表达和脂蛋白动力学，尸检动物以 收集材料来测量最终终点，评估血管病变 控制和治疗动物，准备样品并将其运送到贝勒 休斯敦医学院。